{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:15:20Z","timestamp":1789456520624,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bilateral prophylactic mastectomy (BPM) or contralateral risk\u2010reducing mastectomy (CRRM) are considered in\n                    <jats:italic>CDH1<\/jats:italic>\n                    carriers as a strategy to reduce lobular breast cancer (LBC) risk in women. In this study we aimed to evaluate the overall number of these procedures reported in literature. We conducted a literature search and a scoping review through the PUBMED database. We identified eleven studies eligible for our interest. Overall numbers, frequencies, geographic distribution, family history, and post\u2010operative histopathological findings of BPM or CRRM were the main outcomes considered. Articles reporting information about BPM or CRRM were reported only in Europe and North America. A total of 75 (32.1%) women were treated with any mastectomy (BPM or CRRM), from a population of 234 positive at\n                    <jats:italic>CDH1<\/jats:italic>\n                    genetic testing; 81.3% of these women, were treated in North America and 18.7% in Europe. In total, 69.3% of surgical procedures were BPM and 30.7% were CRRM; 76.9% of BPMs were performed in North America, and 23.1% in Europe. Instead, 91.3% of CRRMs were reported in North America, and 8.7% in Europe, respectively. A positive family history for BC was documented in 81.8% and post\u2010operative histopathological findings described at least one in situ LBC in nearly all breast specimens. In conclusion, BPM or CRRM were performed in about 1\/3 of women with germline\n                    <jats:italic>CDH1<\/jats:italic>\n                    pathogenic or likely pathogenic variants; studies were reported only in Western countries. Family history for BC in\n                    <jats:italic>CDH1<\/jats:italic>\n                    carriers and detection of LCIS in post\u2010operative specimens were also frequently described\n                  <\/jats:p>","DOI":"10.1002\/jso.70323","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T19:00:01Z","timestamp":1783882801000},"page":"475-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral Prophylactic and Contralateral Risk\u2010Reducing Mastectomy in Women With Germline\n                    <i>CDH1<\/i>\n                    Pathogenic or Likely\u2010Pathogenic Variants"],"prefix":"10.1002","volume":"134","author":[{"given":"Giovanni","family":"Corso","sequence":"first","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"},{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-897X","authenticated-orcid":false,"given":"Carlo La","family":"Vecchia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-988X","authenticated-orcid":false,"given":"Francesca","family":"Magnoni","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"},{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Polizzi","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bottazzoli","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra De","family":"Scalzi","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna Di","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Meduri","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-5054","authenticated-orcid":false,"given":"Filippo","family":"Pesapane","sequence":"additional","affiliation":[{"name":"Division of Breast Radiology European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Nicosia","sequence":"additional","affiliation":[{"name":"Division of Breast Radiology European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca De","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Intra","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-4106","authenticated-orcid":false,"given":"Paolo","family":"Veronesi","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery European Institute of Oncology, IRCCS Milan Italy"},{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30219-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/32918"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101472"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.792"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.7862"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12122032"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2014.168"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1208"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2019-105991"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.10852"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13053-024-00293-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6354"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002030"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10754"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26398"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2019.03.053"},{"issue":"3","key":"e_1_2_9_18_1","first-page":"189","article-title":"Is 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