{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:13:59Z","timestamp":1789456439047,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neoadjuvant therapy with immune checkpoint inhibitors (ICIs) is increasingly used in advanced or recurrent melanoma based on outcomes observed in clinical trials. The efficacy and toxicity of this in a real\u2010world setting remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We conducted a retrospective review of adults with cutaneous melanoma who received neoadjuvant ICI as first line therapy at our institution between 2019 and 2024. Patients had advanced melanoma that was surgically resectable and treated with neoadjuvant intent. The primary outcome was pathological response, with a secondary outcome of immune\u2010related toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 81 patients were identified. The median age was 64 (range: 21\u201386). There were 48 males. Most patients received 2 cycles (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953) prior to resection (range: 1\u20137 cycles). Dual ICI was the most common approach (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200962). Disease stage ranged from IIC to IV, with 57% IIIC. Half were pathologic non\u2010responders (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941). Pathologic complete response (pCR) was seen in 25% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), near\u2010pCR in 2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) and partial PR in 10% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098). Ten (12%) patients had a discrepant PR between two or more resected sites. Immune related adverse events were observed in 34 (42%) patients; 21 (26%) grade 1\u20132, and 13 (16%) grade 3\u20134. Overall survival trended towards significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07) for those with mPR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010trial use of neoadjuvant ICI therapy is associated with a less favourable pathological response than reported in clinical trials and similar risks of toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70324","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:32:02Z","timestamp":1784529122000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvant Immune Therapy in Patients With Melanoma: Response and Toxicity in a Non\u2010Clinical Trial Setting"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4912-0052","authenticated-orcid":false,"given":"Orna T.","family":"Cantillon","sequence":"first","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-9601","authenticated-orcid":false,"given":"Klaus J.","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Ariyan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastric and Mixed Tumor Service Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0923-153X","authenticated-orcid":false,"given":"Edmund K.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastric and Mixed Tumor Service Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-4913","authenticated-orcid":false,"given":"Danielle M.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastric and Mixed Tumor Service Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Postow","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA"},{"name":"Department of Medicine Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastric and Mixed Tumor Service Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"StatPearls [Internet]","author":"Heistein J. B.","year":"2024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2402604"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01851-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30151-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211437"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01136"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005459"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy226"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00049"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_2_9_13_1","unstructured":"T. M.Therneau \u201cA Package for Survival Analysis in R \u201d [Internet]. 2026.https:\/\/CRAN.R-project.org\/package=survival."},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"A.Kassambara M.Kosinski andP.Biecek \u201cSurvminer: Drawing Survival Curves Using \u2018ggplot2\u2019\u201d [Internet]. 2025.https:\/\/CRAN.R-project.org\/package=survminerhttps:\/\/doi.org\/10.32614\/CRAN.package.survminer.","DOI":"10.32614\/CRAN.package.survminer"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01998"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.15586\/codon.cutaneousmelanoma.2017.ch9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2024.102127"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004884"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iotech.2025.101078"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-017-0013-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03758-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/mi.2024.137"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7119"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.7333"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211437"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.70324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:53:43Z","timestamp":1789455223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.70324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jso.70324"],"URL":"https:\/\/doi.org\/10.1002\/jso.70324","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}