{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:13:17Z","timestamp":1789456397452,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Salvage surgery is the standard\u2010of\u2010care for patients with squamous cell carcinoma of the anal canal (SCCa) who experience isolated locoregional failure after upfront chemoradiotherapy. While perioperative morbidity and short\u2010term survival outcomes have been described, long\u2010term outcomes of surgical salvage are unknown. This study examines recurrence patterns and survival in a cohort of patients with extended follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective chart review was performed on a cohort of consecutive patients who underwent salvage surgery at two specialized cancer centers between 1987 and 2006. Overall, disease\u2010specific and re\u2010recurrence\u2010free survival (OS, DSS, RRFS) were estimated using the Kaplan\u2010Meier method. Prognostic variables were evaluated using univariate and multivariable Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty patients were included (29 female, 11 male; median age 56). Median follow\u2010up was 16.5 years (IQR 15.0\u221220.5) for patients alive at last follow\u2010up. Re\u2010recurrence developed in 52% of patients, 95% of which occurred within 3 years of salvage surgery; re\u2010recurrence was associated with a 91% risk of subsequent SCCa\u2010specific mortality. DSS was 45% (95% CI 30\u221261) at 5 years, after which point conditional 5\u2010year DSS was 100%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately half of patients who undergo salvage surgery for persistent\/recurrent SCCa experience durable cancer control with extended long\u2010term survival. Emerging treatment options such as immunotherapy should be evaluated relative to this benchmark.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70331","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:42:11Z","timestamp":1784698931000},"page":"604-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Durable Cancer Control and Extended Long\u2010Term Survival Following Salvage Surgery for Squamous Cell Carcinoma of the Anal Canal: A Cohort Study"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-6717","authenticated-orcid":false,"given":"Paul","family":"Savage","sequence":"first","affiliation":[{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Cyr","sequence":"additional","affiliation":[{"name":"Department of 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