{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:58:45Z","timestamp":1790621925051,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The systemic inflammatory response (SIR) is a recognized determinant of outcome in standard colorectal resections, yet its role in exenterative surgery remains unclear. The study aims to evaluate the relationship between peri\u2010operative SIR biomarkers and post\u2010operative complications in pelvic exenterative surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of consecutive patients undergoing pelvic exenteration (PE) or beyond total mesorectal excision (bTME) for primary locally advanced sigmoid and rectal cancers at a tertiary referral center. Clinicopathological variables, peri\u2010operative complications, and SIR biomarkers (C\u2010reactive protein [CRP], albumin, modified Glasgow Prognostic Score [mGPS] and neutrophil) were analyzed. Peri\u2010operative SIR biomarkers and post\u2010operative CRP were assessed as predictors of complications using Firth's penalized logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      114 patients were included; major and infective complications occurred in 29 (25.4%) and 49 (43.0%), respectively. Pre\u2010operatively, high mGPS was associated with ASA\u2009\u2265\u20093, sigmoid tumor location and neutrophilia, whereas neutrophilia was associated with advanced tumor features (T stage and Extramural Venous Invasion), higher CRP, hypoalbuminemia, and ASA\u2009\u2265\u20093. Post\u2010operative\u2010day\u20103 (POD3) CRP\u2009&gt;\u2009150\u2009mg\/L independently predicted major (OR 7.40; 95% CI, 2.45\u201329.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and infective (OR 2.42; 95% CI, 1.09\u20135.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>POD3 CRP\u2009&gt;\u2009150\u2009mg\/L provides dynamic stratification of peri\u2010operative morbidity and may facilitate early detection and targeted management of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70332","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T19:08:45Z","timestamp":1783883325000},"page":"639-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010Operative Systemic Inflammatory Responses Predict Post\u2010Operative Complications in Patients Undergoing Pelvic Exenterative Surgery for Primary Locally Advanced Sigmoid and Rectal Cancer"],"prefix":"10.1002","volume":"134","author":[{"given":"Tin\u2010Ning","family":"Wong","sequence":"first","affiliation":[{"name":"Academic Unit of Surgery and Lister Department of Surgery, Glasgow Royal Infirmary University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-4610","authenticated-orcid":false,"given":"Chia Yew","family":"Kong","sequence":"additional","affiliation":[{"name":"Academic Unit of Surgery and Lister Department of Surgery, Glasgow Royal Infirmary University of Glasgow Glasgow UK"},{"name":"Wolfson Wohl Cancer Research Institute, School of Cancer Sciences, MVLS University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ishak","sequence":"additional","affiliation":[{"name":"Academic Unit of Surgery and Lister Department of Surgery, Glasgow Royal Infirmary University of Glasgow Glasgow UK"},{"name":"Wolfson Wohl Cancer Research Institute, School of Cancer Sciences, MVLS University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Galbraith","sequence":"additional","affiliation":[{"name":"Academic Unit of Surgery and Lister Department of Surgery, Glasgow Royal Infirmary University of Glasgow Glasgow UK"},{"name":"Wolfson Wohl Cancer Research Institute, School of Cancer Sciences, MVLS University of Glasgow Glasgow 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Academic Unit of Surgery and Lister Department of Surgery, Glasgow Royal Infirmary University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin W.","family":"Steele","sequence":"additional","affiliation":[{"name":"Academic Unit of Surgery and Lister Department of Surgery, Glasgow Royal Infirmary University of Glasgow Glasgow UK"},{"name":"Wolfson Wohl Cancer Research Institute, School of Cancer Sciences, MVLS University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/codi.16476","article-title":"The \u2018Pelvic Exenteration Lexicon\u2019: Creating a Common Language for Complex Pelvic Cancer 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