{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:58:16Z","timestamp":1790621896075,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Surgical management of ipsilateral breast tumor recurrence (IBTR) is often mastectomy. No guidelines specifically address contralateral prophylactic mastectomy (CPM) for this population. We assessed factors associated with CPM at the time of IBTR mastectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing mastectomy for IBTR (10\/2008\u20105\/2024) were identified. Demographics, tumor characteristics, and treatment details were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 381 eligible IBTR patients, 221 (58.0%) had a unilateral therapeutic mastectomy and 160 (42.0%) underwent mastectomy with CPM. CPM patients were younger (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), with lower clinical T category tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and less HR\u2009+\u2009HER2\u2010 invasive disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). CPM patients were more likely to undergo germline genetic testing (63.1% vs 41.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and were twice as likely to have immediate breast reconstruction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). On multivariable analysis, younger age, HR\u2010HER2\u2009+\u2009IBTR subtype, pathogenic variants known at the time of surgery (relative to negative testing and\/or no genetic testing), immediate breast reconstruction, and prior radiation for index cancer were each associated with CPM (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our series of 381 patients treated with mastectomy for IBTR, 42% also had a CPM. Multiple factors, including age, tumor stage and biology, immediate breast reconstruction, and genetic testing may impact CPM choice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70339","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:24:30Z","timestamp":1784622270000},"page":"664-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contralateral Prophylactic Mastectomy at the Time of Therapeutic Mastectomy for Local Recurrence of Breast Cancer: Influence of Genetic Testing and Other Factors"],"prefix":"10.1002","volume":"134","author":[{"given":"Candice N.","family":"Santoro","sequence":"first","affiliation":[{"name":"Division of Breast and Melanoma Surgical Oncology, Department of Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney N.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna L.","family":"Sturz\u2010Ellis","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina J.","family":"Hieken","sequence":"additional","affiliation":[{"name":"Division of Breast and Melanoma Surgical Oncology, Department of Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-9651","authenticated-orcid":false,"given":"Mary M.","family":"Mrdutt","sequence":"additional","affiliation":[{"name":"Division of Breast and Melanoma Surgical Oncology, Department of Surgery Mayo Clinic Rochester Minnesota USA"},{"name":"Current Address: Division of Surgical Oncology and Endocrine Surgery Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000005776"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2404-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12197-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23629"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.075"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.02.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.4320"},{"key":"e_1_2_9_9_1","unstructured":"National Comprehensive Cancer Network. 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