{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:44:24Z","timestamp":1785743064398,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>As our population ages, older patients are increasingly presenting for surgical management of advanced malignancies. Hepatectomy for colorectal liver metastasis (CRLM) prolongs survival. The goal of this study was to understand postoperative morbidity and the rate of failure to rescue in older patients undergoing major hepatic resection for CRLM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the American College of Surgeons (ACS) National Surgical Quality Improvement (NSQIP) targeted data set for hepatectomy from 2014 to 2024 to identify patients who underwent major hepatectomy for CRLM. Univariate and multivariable logistic regression analyses were performed to evaluate the risk factors associated with failure to rescue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 4119 patients undergoing hepatectomy for CRLM were included. Age group distribution was as follows: &lt;\u200970 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093346), 70\u201379 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009663), and \u2265\u200980 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009110). Older patients were more likely to experience cardiac complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), post\u2010hepatectomy liver failure (PHLF) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and failure to rescue (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant differences in postoperative outcomes were observed between sexes. Multivariable logistic regression analysis showed that septuagenarians had higher odds of failure to rescue than patients aged &lt;\u200970 years (2.36, 95% CI: 1.29\u20134.33). PHLF (OR 2.98, 95% CI: 1.69\u20135.25) and cardiac complications (OR 21.75, 95% CI: 11.69\u201340.47) were associated with higher odds of failure to rescue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older age was significantly associated with postoperative morbidity and failure to rescue in patients undergoing major hepatectomy for CRLM. We identified cardiac complications and PHLF as potential causes associated with failure to rescue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70356","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:46:46Z","timestamp":1785739606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Associated Morbidity After Major Hepatectomy for Colorectal Liver Metastases"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-2539","authenticated-orcid":false,"given":"Bryant","family":"Morocho","sequence":"first","affiliation":[{"name":"Department of General Surgery, Department of Surgery Guthrie Robert Packer Hospital Sayre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherin","family":"Morocho","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Department of Surgery Guthrie Robert Packer Hospital Sayre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bertsch","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Department of Surgery Guthrie Robert Packer Hospital Sayre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-3807","authenticated-orcid":false,"given":"Burt","family":"Cagir","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Department of Surgery Guthrie Robert Packer Hospital Sayre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Macfie","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Department of Surgery Guthrie Robert Packer Hospital Sayre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12513-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2017.10.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050941"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2022.05.032"},{"issue":"20","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1001\/jama.2014.4573","article-title":"Preoperative Assessment of the Older Patient: A Narrative Review","volume":"311","author":"Oresanya L. B.","year":"2014","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006955"},{"issue":"8","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/MLR.0b013e31829808de","article-title":"Using Present\u2010on\u2010Admission Coding to Improve Exclusion Rules for Quality Metrics: The Case of Failure\u2010to\u2010Rescue","volume":"51","author":"Needleman J.","year":"2013","journal-title":"Medical Care"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.70014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002602"},{"issue":"3","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jso.24506","article-title":"Borderline Operability in Hepatectomy Patients Is Associated With Higher Rates of Failure to Rescue After Severe Complications","volume":"115","author":"Kim B. 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