{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:19:26Z","timestamp":1788164366889,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5K08CA293255\u201002"],"award-info":[{"award-number":["5K08CA293255\u201002"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Text\u2010based pathology reports inadequately communicate complex three\u2010dimensional (3D) relationships in musculoskeletal oncology, potentially contributing to errors in re\u2010resection and adjuvant treatment planning. While our prior 7\u2010case pilot study established technical feasibility, the scalability of this workflow and its utility as a platform for further innovation have not been demonstrated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective implementation study of 36 musculoskeletal oncology specimens at a tertiary sarcoma center between April 2023 and November 2025. Specimens underwent ex vivo 3D scanning using a structured light scanner, followed by virtual annotation using computer\u2010aided design software to mirror the standard\u2010of\u2010care grossing process and create visual pathology reports (VPRs). The primary outcome was systematic implementation without disrupting standard processing. Secondary outcomes included platform\u2010derived applications: augmented reality (AR)\u2010guided re\u2010resection, 3D margin heat maps, and 3D wound\u2010bed scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All 36 specimens were scanned and mapped (21 soft tissue, 13 bone, 2 metastatic; median greatest specimen dimension 12.7\u2009cm). Positive margins occurred in 13.9% (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20095) of cases. VPRs were presented in multidisciplinary tumor boards in three of these five cases. AR guidance was implemented in eight staged\u2010resection cases (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094 for positive margin re\u2010resection,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094 for pre\u2010reconstruction planning), 3D heat maps were created for eight cases, and intraoperative wound bed scanning was piloted once.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion\/Conclusion<\/jats:title>\n                    <jats:p>3D specimen scanning and virtual mapping are scalable workflows providing a permanent visual record of resected specimens and functioning as a foundational platform for novel interventions. AR\u2010guided surgery and 3D heat mapping demonstrate potential paradigm shifts from static reporting to dynamic, visual pathologic reporting and surgical guidance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70382","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:08:40Z","timestamp":1788163720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Applications of 3D Specimen Scanning and Margin Mapping in Musculoskeletal Oncology: A 36 Patient Case Series"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-2905","authenticated-orcid":false,"given":"Riley S.","family":"Gilbertson","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine Nashville Tennessee 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Musculoskeletal Oncology Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0256-0516","authenticated-orcid":false,"given":"Reena","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-2755","authenticated-orcid":false,"given":"Jennifer L.","family":"Halpern","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Division of Musculoskeletal Oncology Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert S.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Division of Musculoskeletal Oncology Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-4417","authenticated-orcid":false,"given":"Michael C.","family":"Topf","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4069-7044","authenticated-orcid":false,"given":"Joshua M.","family":"Lawrenz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Division of Musculoskeletal Oncology Vanderbilt University Medical Center Nashville Tennessee 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