{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:06:14Z","timestamp":1790762774557,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Studies have shown that obesity increases the risk of postmenopausal breast cancer (BC) by 30%\u201360% and is associated with poorer outcomes. This is believed to be related to continued exposure to estrogen and prolonged inflammation. Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) have been suggested to significantly lower the risk of several obesity\u2010associated cancers (OACs). We hypothesize that GLP\u20101RAs can improve outcomes in peri\u2010 and postmenopausal BC patients with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study using the TriNetX database to compare the outcomes of female BC patients \u2265\u200945 years old with a BMI of \u2265\u200935\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . We created two cohorts: those who took GLP\u20101RAs with a Stage I\u2010III BC diagnosis and those who never had exposure to GLP\u20101RAs. Patients' propensity score was matched based on age, BMI, diabetes, socioeconomic status, and genetic carrier status. Our outcomes of interest were 10\u2010year overall survival (OS) and local recurrence (LR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 10\u2009498 patients who used GLP\u20101RAs and 93\u2009174 patients who did not. After matching, 19\u2009348 patients were identified, with 9674 per cohort. 10\u2010year OS with the Kaplan\u2010Meier analysis was significantly greater in patients on GLP\u20101RAs (79%) compared to those not on GLP\u20101RAs (71%), log\u2010rank test\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001. The HR for OS was 0.54, 95% CI (0.49\u20130.60). The risk of LR was significantly lower (HR 0.481, 95% CI (0.425\u20130.546)).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Among peri\u2010 and postmenopausal breast cancer patients with BMI\u2009\u2265\u200935\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , GLP\u20101RA use after diagnosis was associated with improved 10\u2010year OS and lower LR. These findings are hypothesis\u2010generating but suggest a potential therapeutic role for GLP\u20101RAs, warranting prospective investigation in this high\u2010risk population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70411","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:52:36Z","timestamp":1790761956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Glucagon\u2010Like Peptide 1 Receptor Agonists on Peri\u2010 and Postmenopausal Breast Cancer Outcomes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-3778","authenticated-orcid":false,"given":"Jennifer","family":"Den","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Texas Medical Branch at Galveston Galveston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3263-2128","authenticated-orcid":false,"given":"Nicole","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Texas Medical Branch at Galveston Galveston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Vaghjiani","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Texas Medical Branch at Galveston Galveston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Suzanne Klimberg","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Texas Medical Branch at Galveston Galveston Texas 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