{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:45:40Z","timestamp":1791798340892,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010477","name":"Intuitive Surgical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Among patient with early\u2010stage breast cancer, breast conservation surgery (BCS) is the most performed surgery, utilized in approximately two\u2010thirds of patients. While 5\u2010year overall\u2010survival rates are strong\u2014typically above 90%\u2014additional re\u2010excisions can occur in up to 25% of patients who undergo index BCS and some patients will require subsequent surgery for new breast cancer or recurrences. As such, these additional procedures can complicate patients\u2019 pathway to survivorship, negatively impact quality of life, and lead to excess healthcare costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used linked claims and an electronic healthcare record database to (1) characterize patients at higher risk for additional breast oncologic surgery (aBOS) following BCS, and (2) quantify the long\u2010term financial impact of aBOS after BCS. In total, 87,190 patients with breast cancer, who had an index BCS between January 1, 2012, to March 31, 2023, were followed for up to 5\u2010years post\u2010operatively. Patients with and without aBOS were analyzed, comparing demographics, tumor characteristics, healthcare utilization, and per\u2010person\u2010per\u2010month (PPPM) costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three percent (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920,212) of patients underwent aBOS. These patients were younger, had higher tumor grades and larger tumor sizes, and incurred greater healthcare costs compared to patients who did not undergo a secondary surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights significant factors influencing BCS outcomes and healthcare utilization, underscoring the need for tailored therapeutic strategies for patients with breast cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70419","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:55:10Z","timestamp":1791795310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repeat Breast Cancer Surgeries After Segmental Mastectomy Meaningfully Increase Long Term Healthcare Costs"],"prefix":"10.1002","author":[{"given":"Alexandra L.","family":"Mathews","sequence":"first","affiliation":[{"name":"Endeavor Health Evanston Illinois USA"},{"name":"University of Chicago Pritzker School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-8258","authenticated-orcid":false,"given":"Mara A.","family":"Piltin","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-966X","authenticated-orcid":false,"given":"Sam E.","family":"Wing","sequence":"additional","affiliation":[{"name":"Intuitive Surgical, Inc Sunnyvale California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi C.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Intuitive Surgical, Inc Sunnyvale California 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