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A composite TE\u2010IVD was previously developed and evaluated in rat tail and beagle cervical spine models in vivo. Although cell viability and tissue integration into host tissue were promising, significant implant displacement occurred at multiple spinal levels. The goal of the present study was to assess the effects of a resorbable plating system on the stiffness of motion segments and stability of tissue\u2010engineered implants subjected to axial compression. Canine motion segments from levels C2\/C3 to C5\/C6 were assessed as intact (CTRL), after discectomy (Dx), with an implanted TE\u2010IVD only (PLATE\u2212), and with a TE\u2010IVD combined with an attached resorbable plate (PLATE+). Segments under PLATE+ conditions fully restored separation between endplates and showed significantly higher compressive stiffness than segments under PLATE\u2212 conditions. Plated segments partially restored more than 25% of the CTRL motion segment stiffness. Plate attachment also prevented implant extrusion from the disc space at 50% compressive strain, and this effect was more significant in segments from levels C3\/C4 when compared to segments from level C5\/C6. These results suggest that stabilization of motion segments via resorbable plating assists TE\u2010IVD retention in the disc space while allowing the opportunity for implants to fully integrate into the host tissue and achieve optimal restoration of spine biomechanics.<\/jats:p>","DOI":"10.1002\/jsp2.1031","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:37:43Z","timestamp":1533616663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Resorbable plating system stabilizes tissue\u2010engineered intervertebral discs implanted ex vivo in canine cervical spines"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-1759","authenticated-orcid":false,"given":"Jorge A.","family":"Mojica\u2010Santiago","sequence":"first","affiliation":[{"name":"Meinig School of Biomedical Engineering Cornell University  Ithaca New 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