{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:41:15Z","timestamp":1781826075171,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JOR Spine"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Abaloparatide is a parathyroid hormone receptor agonist that increases bone formation and reduces vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis. Animal studies indicate abaloparatide stimulates vertebral bone formation and enhances bony bridging and biomechanical stability of fracture calluses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The current study is evaluating the potential utility for abaloparatide as an adjunct therapy for spinal fusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The effects of 14 or 28\u2009days of daily subcutaneous injections of abaloparatide (20\u2009\u03bcg\/kg\/d) or vehicle were evaluated in 32 male Sprague\u2010Dawley rats starting 1\u2009day after noninstrumented posterolateral fusion (PLF) with bone autograft. Fusion mass microarchitecture was analyzed by micro\u2010computed tomography (micro\u2010CT) and serum markers of bone formation and bone resorption were evaluated. Motion segments were scored in a blinded manner as fused or unfused by postmortem radiography and manual palpation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abaloparatide\u2010treated rats showed higher bone formation (serum osteocalcin) at day 14 and 28 compared with vehicle controls, without increases in the bone resorption marker serum TRACP\u20105b. Micro\u2010CT showed greater trabecular number in fusion masses from the abaloparatide group vs vehicle controls at day 14. Manual palpation and radiography indicated no fusions in either group at day 14, whereas 25% of vehicle\u2010treated rats and 50% of abaloparatide\u2010treated rats had bilateral fusion at day 28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>In summary, this rat PLF model showed that abaloparatide treatment was associated with higher levels of the bone formation marker osteocalcin, improved fusion mass architecture, and a non\u2010 significant 2\u2010fold higher fusion rate compared with vehicle.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsp2.1132","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T19:40:00Z","timestamp":1606333200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of systemically administered abaloparatide, an osteoanabolic <scp>PTHrP<\/scp> analog, as an adjuvant therapy for spinal fusion in rats"],"prefix":"10.1002","volume":"4","author":[{"given":"Heike","family":"Arlt","sequence":"first","affiliation":[{"name":"Research &amp; Development Radius Health, Inc.  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