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The incidence of this condition has gradually risen in recent years because of increases in spine\u2010related surgery and hospital\u2010acquired infections, an aging population, and intravenous (IV) drug use. Spine infections are most commonly caused by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , while other systemic infections such as tuberculosis and brucellosis can also cause spondylitis. Various animal models of vertebral osteomyelitis and associated infections have been investigated in mouse, rat, chicken, rabbit, dog, and sheep models by hematogenous and direct inoculation in surgery, each with their strengths and limitations. This review is the first of its kind to concisely analyze the various existing animal models used to reproduce clinically relevant models of infection. Spine\u2010related infection models must address the unique anatomy of the spine, the avascular nature of its structures and tissues and the consequences of tissue destruction such as spinal cord compression. Further investigation is necessary to elucidate the specific mechanisms of host\u2010microbe response to inform antimicrobial therapy and administration techniques in a technically demanding body cavity. Small\u2010animal models are not suitable for large instrumentation, and difficult IV access thwarts antibiotic administration. In contrast, large\u2010animal models can be implanted with clinically relevant instrumentation and are resilient to repeat procedures to study postoperative infection. A canine model of infection offers a unique opportunity to design and investigate antimicrobial treatments through recruitment a rich population of canine patients, presenting with a natural disease that is suitable for randomized trials.\n                  <\/jats:p>","DOI":"10.1002\/jsp2.1142","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T08:46:25Z","timestamp":1614674785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-9784","authenticated-orcid":false,"given":"Kieran","family":"Joyce","sequence":"first","affiliation":[{"name":"C\u00daRAM SFI Research Centre for Medical Devices National University of Ireland Galway Ireland"},{"name":"School of Medicine 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