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The muscles attaching to the spine (ie, paraspinal muscles) are critical for proper spine health and play a crucial role in the functioning of the spine and whole body; however, reports of muscle dysfunction and insufficiency in chronic LBP (CLBP) patients are common. This article presents a review of the current understanding of the relationship between paraspinal muscle pathophysiology and spine\u2010related disorders. Human literature demonstrates a clear association between altered muscle structure\/function, most notably fatty infiltration and fibrosis, and low back pain disorders; other associations, including muscle cell atrophy and fiber type changes, are less clear. Animal literature then provides some mechanistic insight into the complex relationships, including initiating factors and time courses, between the spine and spine muscles under pathological conditions. It is apparent that spine pathology can directly lead to changes in the paraspinal muscle structure, function, and biology. It also appears that changes to the muscle structure and function can directly lead to changes in the spine (eg, deformity); however, this relationship is less well studied. Future work must focus on providing insight into possible mechanisms that regulate spine and paraspinal muscle health, as well as probing how muscle degeneration\/dysfunction might be an initiating factor in the progression of spine pathology.<\/jats:p>","DOI":"10.1002\/jsp2.1171","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T12:30:08Z","timestamp":1631709008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders"],"prefix":"10.1002","volume":"4","author":[{"given":"Alex M.","family":"Noonan","sequence":"first","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-6265","authenticated-orcid":false,"given":"Stephen H. 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