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Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Two hundred and forty TwinsUK cohort participants with both MRI disc degeneration grade and Modic change extent, and IL\u20106, IL\u20108, IL\u20108 TNF, and CX3CL1 protein blood concentration measurements were included in this work. Linear mixed effects models were used to test the association of blood cytokine concentration with disc degeneration score and Modic change volumetric score. Association of chronic LBP status from questionnaires with disc degeneration, Modic change, and cytokine blood concentration was also tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistically significant association between disc degeneration or Modic change with cytokine blood concentration was found. Instead, regression analysis pointed strong association between cytokine blood concentration with body mass index for IL\u20106 and with age for IL\u20106 and TNF. Mild association was found between IL\u20108 blood concentration and body mass index. Additionally, LBP status was associated with Modic change volumetric score but not associated with any cytokine concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found no evidence that Modic change and disc degeneration are able to produce changes in tested blood cytokine concentration. However, age and body mass index have strong influence on cytokine concentration and both are associated with the conditions studied which may confound associations found in the literature. It is then unlikely that cytokines produced in the disc or vertebral bone marrow induce chronic LBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsp2.1323","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T05:09:25Z","timestamp":1711343365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-1092","authenticated-orcid":false,"given":"Roger","family":"Compte","sequence":"first","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-6259","authenticated-orcid":false,"given":"Maxim B.","family":"Freidin","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Biological and Behavioural Sciences Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-3317","authenticated-orcid":false,"given":"Isabelle","family":"Granville Smith","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-7107","authenticated-orcid":false,"given":"Christine L.","family":"Le Maitre","sequence":"additional","affiliation":[{"name":"Division of Clinical Medicine, School of Medicine and Population Health University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dovile","family":"Vaitkute","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayrun","family":"Nessa","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve","family":"Lachance","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-2744","authenticated-orcid":false,"given":"Frances M. 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