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In this systematic review, the effectuated improvements in pain, disability, quality of life (QoL), and radiographic images are comprehensively described and scored on their clinical significance. An electronic database literature search was conducted on July 2023 for in\u2010human assessment of cell or PRP products to alleviate discogenic pain. Papers were screened on quantitative pain, disability, QoL, radiographic improvements, and safety outcomes. Risk of bias was assessed through MINORS and Cochrane Source of Bias tools. Reported outcomes were obtained, calculated, and assessed to meet minimal clinically important difference (MCID) standards. From 7623 screened papers, a total of 80 articles met the eligibility criteria, presenting 68 specific studies. These presented at least 1974 treated patients. Overall, cell\/PRP injections could alleviate pain and disability, resulting in MCID for pain and disability in up to a 2\u2010year follow\u2010up, similar to those observed in patients undergoing spinal fusion. Included trials predominantly presented high levels of bias, involved heterogeneous study designs, and only a minimal number of randomized controlled trials. Nonetheless, a clear clinically significant impact was observed for cell\u2010 and PRP\u2010treated cohorts with overall good safety profiles. These results highlight a strong therapeutic potential but also underline the need for future cost\u2010effectiveness assessments to determine the benefits of cell\/PRP treatments.<\/jats:p>","DOI":"10.1002\/jsp2.1348","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T06:09:37Z","timestamp":1719295777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A comprehensive review of cell transplantation and platelet\u2010rich plasma therapy for the treatment of disc degeneration\u2010related back and neck pain: A systematic evidence\u2010based analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-2591","authenticated-orcid":false,"given":"Jordy","family":"Schol","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Tokai University School of Medicine  Isehara Japan"},{"name":"Tokai University Center of Regenerative Medicine  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Tamagawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tokai University School of Medicine  Isehara Japan"},{"name":"Department of Medicine for Orthopaedics and Motor Organ Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibo Nico Emmie","family":"Volleman","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tokai University School of Medicine  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneaki","family":"Ishijima","sequence":"additional","affiliation":[{"name":"Department of Medicine for Orthopaedics and Motor Organ Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-9270","authenticated-orcid":false,"given":"Daisuke","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tokai University School of Medicine  Isehara Japan"},{"name":"Tokai University Center of Regenerative Medicine  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Precedence Research.Cell therapy market\u2014global industry analysis size share growth trends regional outlook and forecast 2022\u20132030.https:\/\/www.precedenceresearch.com\/table-of-content\/1700. 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