{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:30:33Z","timestamp":1777365033847,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160874"],"award-info":[{"award-number":["82160874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JOR Spine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Arthritis and low back pain (LBP) are prevalent musculoskeletal conditions with a perceived association. Previous observational studies have suggested a possible link between arthritis and LBP, but causality has not been firmly established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The analysis involved data from a meta\u2010analysis of genome\u2010wide association studies sourced from the UK Biobank Genetics resources on rheumatoid arthritis (RA), osteoarthritis (OA) at any site, knee osteoarthritis (KOA), hip osteoarthritis (HOA), and LBP. Two\u2010sample Mendelian randomization analysis was utilized to evaluate the causal link between arthritis and LBP. The primary method employed was inverse\u2010variance weighting (IVW), with additional techniques such as MR\u2010Egger, weighted median, Cochran <jats:italic>Q<\/jats:italic> statistic, and leave\u2010one\u2010out analysis used to identify heterogeneity and pleiotropy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Genetically determined RA exhibited a causal impact on LBP (Weighted median: odds ratio [OR]\u2009=\u20091.094, 95% confidence interval [CI] 1.002\u20131.195, <jats:italic>p<\/jats:italic>\u2009=\u20090.043). Furthermore, OA at any site and KOA showed causal associations with LBP (Inverse variance weighted: OR\u2009=\u20091.089, 95% CI 1.011\u20131.173, <jats:italic>p<\/jats:italic>\u2009=\u20090.026) and (OR\u2009=\u20091.0004, 95% CI 1.000\u20131.008, <jats:italic>p<\/jats:italic>\u2009=\u20090.019), respectively. Additionally, HOA was also linked causally with an elevated risk of developing LBP (Weighted median: OR\u2009=\u20091.002, 95% CI 1.000\u20131.004, <jats:italic>p<\/jats:italic>\u2009=\u20090.049; Inverse variance weighted: OR\u2009=\u20091.002, 95% CI 1.001\u20131.004, <jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study offers genetic evidence supporting the causal relationship between RA, OA at any site, KOA, HOA and the increased risk of LBP, especially highlighting the significant impact of HOA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsp2.70023","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T12:39:31Z","timestamp":1734093571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The genetic causal association between arthritis and low back pain"],"prefix":"10.1002","volume":"7","author":[{"given":"Aimin","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine Hainan Medical University  Haikou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-7177","authenticated-orcid":false,"given":"Mengjie","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University  Melbourne Victoria 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