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Although adipokine dysregulation has been widely implicated in the pathogenesis of cardiovascular, gastrointestinal, nervous, immune, and musculoskeletal disorders\u2010 especially osteoarthritis, rheumatoid arthritis, and osteoporosis\u2010 their involvement in spinal pathology remains comparatively underinvestigated. Recent evidence indicates that certain adipokines may influence spinal disease progression by affecting bone, intervertebral discs, musculature, and neural structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature review was conducted to evaluate preclinical and clinical studies investigating the role of adipokines in spinal pathology. PubMed and related databases were searched for studies reporting associations between adipokine expression and structural or functional changes in spinal tissues, including vertebral bone, intervertebral discs, paraspinal muscles, spinal ligaments, and the spinal cord. Particular attention was given to mechanistic insights and translational relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The review identified emerging evidence implicating several adipokines, including leptin, adiponectin, resistin, and visfatin, in degenerative and inflammatory changes across various spinal structures. Adipokines were found to influence matrix degradation, bone turnover, muscle atrophy, and neural inflammation through cytokine signaling, oxidative stress, and metabolic dysregulation. However, findings are often heterogeneous and context\u2010dependent, with limited longitudinal or interventional data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adipokines represent a promising yet underexplored avenue in spinal disease research. Their diverse functions in both structural and metabolic regulation highlight their potential as both biomarkers and therapeutic targets. Further mechanistic and clinical studies are needed to elucidate causal relationships and therapeutic efficacy, particularly in degenerative spine disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsp2.70083","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T05:25:17Z","timestamp":1749014717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Adipokines in Spinal Disease: A Narrative Review"],"prefix":"10.1002","volume":"8","author":[{"given":"Jake M.","family":"McDonnell","sequence":"first","affiliation":[{"name":"National Spinal Injuries Unit Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Darwish","sequence":"additional","affiliation":[{"name":"National Spinal Injuries Unit Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"Department of Orthopaedics St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Butler","sequence":"additional","affiliation":[{"name":"National Spinal Injuries Unit Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin  Dublin Ireland"},{"name":"School of Medicine University of College Dublin  Belfield, Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-4534","authenticated-orcid":false,"given":"Conor T.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin  Dublin Ireland"},{"name":"Discipline of Mechanical, Manufacturing and Biomedical Engineering School of Engineering, Trinity College Dublin, the University of Dublin  Dublin Ireland"},{"name":"Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland &amp; Trinity College Dublin The University of Dublin  Dublin Ireland"},{"name":"Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"1","article-title":"The Unfolding Tale of Leptin","volume":"8","author":"Jeet S. 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