{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:45:12Z","timestamp":1789472712116,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U19AR076725"],"award-info":[{"award-number":["U19AR076725"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JOR Spine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The chronic low back pain (cLBP) literature rarely includes comprehensive characterization of demographic and biomedical factors in a large sample of individuals. The University of Pittsburgh Mechanistic Research Center, entitled, \u201cLow Back Pain: Biological, Biomechanical, Behavioral Phenotypes (LB\n                      <jats:sup>3<\/jats:sup>\n                      P),\u201d is part of the National Institutes of Health's Helping to End Addiction Long\u2010term Initiative. The LB\n                      <jats:sup>3<\/jats:sup>\n                      P conducted a prospective, observational cohort study to identify phenotypes of people with cLBP. Here, we report demographic and biomedical characteristics of a large cohort of individuals with cLBP, stratified by sex and age, collected at the in\u2010person enrollment visit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The key eligibility criteria were adults with cLBP, English speakers, and identified in the electronic health record of our medical center. Recruitment strategies were through clinical partners who invited their patients to join the study and research registries. Participants completed demographic and biomedical surveys. Descriptive statistics were computed for the sample overall, and for the subgroups (male\/female and age\u2009&lt;\u200960\/\u2265\u200960).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091007 individuals (60% female) were enrolled, with an average age of 59\u2009\u00b1\u200917\u2009years. Most participants were non\u2010Hispanic (90%), White (75%), and 53% attained college or higher education. 54% were married or had a partner, 43% were employed, 38% retired, 41% had an annual household income &lt;\u2009$50\u2009000, 20% had been off work for more than 30\u2009days due to low back pain (LBP), 16% had applied for or received disability, and 6% were on worker's compensation. The majority were obese (average BMI of 31.5 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), 61% had back pain for &gt;\u20095\u2009years, and pain had been ongoing every or nearly every day in 76% of the sample. The participants reported a high prevalence of osteoarthritis (58%), anxiety (40%), depression (40%), vision impairment (35%), and balance problems\/falls (31%). Among the chronic overlapping pain conditions, the most common were migraine or headache (29%), irritable bowel syndrome (16%), and temporomandibular joint dysfunction (12%). Previous low back surgery was reported by 25%. The most frequently reported LBP treatments during the previous month were exercise routine done on their own (58%), physical therapy, occupational therapy, or chiropractic care (33%), mindfulness, meditation, or relaxation (22%), and diet or nutrition counseling (21%). Medication intake during the last month was 43% for nonsteroidal anti\u2010inflammatory drugs, 18% for gabapentin, 13% for opioid, and 10% for antidepressants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Describing comprehensive demographic and biomedical characteristics of individuals with cLBP stratified by sex and age will serve as a reference for clinicians and research planning, particularly with respect to comorbid conditions and utilization of treatment for cLBP. These data will be useful in future efforts to comprehensively phenotype cLBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsp2.70094","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T15:58:22Z","timestamp":1752508702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Demographic and Biomedical Characteristics of an Observational Cohort With Chronic Low Back Pain: A Descriptive Analysis"],"prefix":"10.1002","volume":"8","author":[{"given":"Sara R.","family":"Piva","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Pittsburgh School of Health and Rehabilitation Science  Pittsburgh Pennsylvania USA"},{"name":"Clinical and Translational Science Institute University of Pittsburgh  Pittsburgh Pennsylvania 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J.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Doctor of Chiropractic Program University of Pittsburgh School of Health and Rehabilitation Science  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn A.","family":"Sowa","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Orthopaedic Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Bioengineering University of Pittsburgh Swanson School of Engineering  Pittsburgh Pennsylvania USA"},{"name":"Department of Physical Medicine and Rehabilitation University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Ferguson Laboratory for Orthopaedic and Spine Research 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Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leming","family":"Zhou","sequence":"additional","affiliation":[{"name":"McGowan Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Health Information Management University of Pittsburgh School of Health and Rehabilitation Sciences  Pittsburgh Pennsylvania USA"},{"name":"Intelligent Systems Program University of Pittsburgh School of Computing and Information  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-0124","authenticated-orcid":false,"given":"Charity G.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Pittsburgh School of Health and Rehabilitation Science  Pittsburgh Pennsylvania 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