{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:37:43Z","timestamp":1787240263230,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JOR Spine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paraspinal muscle degeneration, particularly fat infiltration, is a prominent feature of adult degenerative scoliosis (ADS), which impairs spinal stability, accelerates disease progression, and contributes to poor clinical outcomes. However, the underlying molecular mechanisms remain unclear. This study aims to investigate the role of the hsa_circ_0006156\/miR\u2010122\u20105p\/PPARA regulatory axis in this process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Paraspinal muscle fat infiltration was assessed by MRI in ADS patients and 40 age\u2010matched controls. HE staining, Oil Red O staining, and RT\u2010PCR were used to evaluate muscle structure and gene expression. Overexpression of hsa_circ_0006156 and inhibition of miR\u2010122\u20105p were performed in primary multifidus muscle cells. Western blot and dual\u2010luciferase reporter assays were used to verify the regulatory pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Paraspinal muscle fat infiltration was significantly increased in ADS patients and showed clear asymmetry. hsa_circ_0006156 was downregulated on the concave side. Its overexpression reduced lipid accumulation, downregulated adiponectin and perilipin, and increased PPARA expression. Bioinformatics analysis and luciferase assays confirmed miR\u2010122\u20105p as a direct target of hsa_circ_0006156, and PPARA as a downstream gene of miR\u2010122\u20105p. Inhibiting miR\u2010122\u20105p reduced fat accumulation and increased PPARA expression. Co\u2010transfection assays showed that hsa_circ_0006156 regulates lipid metabolism by sponging miR\u2010122\u20105p and releasing its inhibition on PPARA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Paraspinal muscles in ADS patients show marked fat infiltration with lateral asymmetry, especially on the concave side. hsa_circ_0006156 regulates lipid metabolism through the miR\u2010122\u20105p\/PPARA axis and reduces fat deposition, providing a potential molecular target for early diagnosis and intervention in ADS\u2010related muscle degeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsp2.70146","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:57:22Z","timestamp":1764557842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling the Potential Mechanism of Asymmetric Fat Infiltration in Paraspinal Muscles of Adult Degenerative Scoliosis: The Role of the Hsa_circ_0006156\/\n                    <scp>miR<\/scp>\n                    \u2010122\u20105p\/\n                    <scp>PPARA<\/scp>\n                    Regulatory Network"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4760-4511","authenticated-orcid":false,"given":"Xueneng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Traumatic Orthopedics The Second Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2257-3109","authenticated-orcid":false,"given":"Limin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics The Second Affiliated Hospital of Kunming Medical University  Kunming 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