{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:26:00Z","timestamp":1774355160431,"version":"3.50.1"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AR083844"],"award-info":[{"award-number":["T32AR083844"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32AR082276"],"award-info":[{"award-number":["F32AR082276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JOR Spine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intervertebral disc (IVD) degeneration contributes significantly to chronic low back pain and represents a major clinical challenge. Quantitative MRI (qMRI) techniques offer the potential to assess biochemical and structural disc changes noninvasively, but its use has been slow to be incorporated into studies utilizing spontaneous large animal models. This study characterizes qMRI\u2010derived biomarkers of IVD degeneration across the lifespan in a clinically relevant ovine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ex vivo thoracolumbar spine segments from 10 sheep (13\u2013130 months old) were assessed using 3T MRI, including T2, T2*, T1\u03c1, adiabatic T1\u03c1, adiabatic T2\u03c1, and ADC mapping. Relaxation times were compared with Pfirrmann grade, disc height index, biomechanical testing, GAG\/water content, and histological scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>T2 and T2* values in the nucleus pulposus (NP) were negatively correlated with age, Pfirrmann grade, and histological degeneration, and positively correlated with GAG and water content. T2 relaxation times in the annulus fibrosus (AF) were inversely related to biomechanical stiffness, whereas T2* relaxation times in the NP were positively associated. Strong inter\u2010metric correlations were observed between most qMRI measures, but aT1\u03c1 and ADC showed more distinct profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support the sensitivity of qMRI in detecting regional and age\u2010related IVD changes and reinforce its utility for noninvasive disc assessment in translational models of degeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsp2.70169","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:03:18Z","timestamp":1773745398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Ovine Intervertebral Disc Health Across the Lifespan: Relationships Between Quantitative\n                    <scp>MRI<\/scp>\n                    , Radiological, Histological, Biochemical, and Biomechanical Assessments"],"prefix":"10.1002","volume":"9","author":[{"given":"Yaqoub","family":"Yusuf","sequence":"first","affiliation":[{"name":"Divisions of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca E.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Divisions of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Physical Medicine &amp; Rehabilitation University of Colorado Anschutz  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick O.","family":"Buko","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota  Saint Paul Minnesota 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