{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:46:28Z","timestamp":1782301588229,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH3AR076724"],"award-info":[{"award-number":["UH3AR076724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JOR Spine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this investigation was to explore the association between disk degeneration, quantified by Pfirrmann grades and T1rho as a marker of hydration, and bone remodeling in the vertebral endplate quantified by Na[\n                      <jats:sup>18<\/jats:sup>\n                      F]F uptake on PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Subjects for this exploratory, post hoc analysis were selected from a prospective observational study on low back pain. Subjects received simultaneous Na[\n                      <jats:sup>18<\/jats:sup>\n                      F]F\u2010PET and spinal MRI (including T1rho mapping) in a hybrid scanner system. Tracer uptake (SUV\n                      <jats:sub>max<\/jats:sub>\n                      ) was quantified per endplate, and quantitative disk metrics were measured for annulus fibrosus and nucleus pulposus separately. Disk degeneration (Pfirrman grade) and endplate lesions (Modic changes) were assessed by a radiologist. Linear mixed models were used to investigate the association between quantitative disk and metabolic endplate metrics, adjusting for age, sex, body mass index, as well as Pfirrmann grade and Modic changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010six endplates from 9 patients (6 women) with median age 58\u2009years (IQR: 53\u201372) were included. We found a positive association between annular T1rho and endplate Na[\n                      <jats:sup>18<\/jats:sup>\n                      F]F uptake (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.088; 95% CI 0.018\u20130.159). The association was amplified by the presence of Modic changes (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that bone remodeling of vertebral endplates is not associated with disk dehydration, and thus more likely a result of biological disk\u2010endplate crosstalk than a sign of increased mechanical load.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsp2.70188","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:41:12Z","timestamp":1780904472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Disk and Metabolic Bone\n                    <scp>PET<\/scp>\n                    \u2010\n                    <scp>MRI<\/scp>\n                    for Understanding Disk\u2010Endplate Crosstalk in Degeneration of the Lumbar Spine"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7378-1068","authenticated-orcid":false,"given":"Virginie","family":"Kreutzinger","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"},{"name":"Department of Neuroradiology TUM Klinikum, Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Ziegeler","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misung","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia T.","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupsa","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"},{"name":"Department of Medical Science and Technology Indian Institute of Technology Madras  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Remick","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bahroos","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California 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