{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:29:03Z","timestamp":1791660543867,"version":"4.3.4"},"reference-count":283,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["CIRM EDUC4\u201012751"],"award-info":[{"award-number":["CIRM EDUC4\u201012751"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["DISC2\u201014049"],"award-info":[{"award-number":["DISC2\u201014049"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01AR079485"],"award-info":[{"award-number":["NIH R01AR079485"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 1R01AR082041"],"award-info":[{"award-number":["NIH 1R01AR082041"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JOR Spine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell\u2010based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes. Accumulating evidence suggests that therapeutic failure reflects not only limitations in cell source or differentiation potential, but also the hostile biochemical and biomechanical microenvironment of the degenerative disc. Hypoxia, nutrient deprivation, acidity, lactate accumulation, fibrosis, senescence, inflammation, and abnormal mechanical loading collectively impair cell survival, integration, and long\u2010term function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We performed a comprehensive review of the literature using PubMed, Web of Science, and Google Scholar, with emphasis on studies published between 2020 and 2026. Evidence was critically evaluated to examine advances in cell\u2010based therapies for IVDD, including cell sources, mechanisms of repair, biomaterial\u2010assisted delivery systems, microenvironment\u2010targeted strategies, translational studies, and emerging technologies that enhance regenerative efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Current evidence indicates that successful disc regeneration depends not only on selecting an appropriate therapeutic cell source but also on overcoming the biological constraints imposed by the degenerative niche. We critically compare the regenerative potential of mesenchymal stromal cells, nucleus pulposus cells, and induced pluripotent stem cell\u2010derived therapies, highlighting their respective advantages and limitations. We further discuss how biomaterial carriers, extracellular vesicles, developmental biology\u2010guided differentiation, genetic engineering, preconditioning approaches, and smart delivery platforms are being integrated to improve cell survival, phenotype stability, extracellular matrix restoration, and functional repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Future success in intervertebral disc regeneration will require integrated therapeutic strategies that combine optimized cell sources with biomaterial\u2010assisted delivery, microenvironment modulation, and precision bioengineering. Advancing these complementary approaches will be essential for achieving durable biological repair, restoring disc structure and function, and translating regenerative therapies into effective clinical treatments for patients with degenerative disc disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsp2.70207","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:05:09Z","timestamp":1785938709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surviving the Nucleus Pulposus Desert: Next\u2010Generation Strategies for Intervertebral Disc Cell Therapy"],"prefix":"10.1002","volume":"9","author":[{"given":"Tynhinane","family":"Hamidouche","sequence":"first","affiliation":[{"name":"Orthopedic Stem Cell Research Lab, Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Board of Governors Regenerative Medicine Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7906-1310","authenticated-orcid":false,"given":"Namdev","family":"More","sequence":"additional","affiliation":[{"name":"Orthopedic Stem Cell Research Lab, Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Board of Governors Regenerative Medicine Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1386-1210","authenticated-orcid":false,"given":"Tiffany","family":"Lee","sequence":"additional","affiliation":[{"name":"Orthopedic Stem Cell Research Lab, Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Board of Governors Regenerative Medicine Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1578-6985","authenticated-orcid":false,"given":"Mia","family":"Orr","sequence":"additional","affiliation":[{"name":"Orthopedic Stem Cell Research Lab, Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Board of Governors Regenerative Medicine Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-0407","authenticated-orcid":false,"given":"Anne","family":"Camus","sequence":"additional","affiliation":[{"name":"Nantes University, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229 Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-1678","authenticated-orcid":false,"given":"Devina","family":"Purmessur","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Ohio State University Columbus Ohio USA"},{"name":"Department of Orthopaedics, College of Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-6606","authenticated-orcid":false,"given":"Sarah E.","family":"Gulbrand","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Translational Musculoskeletal Research Center CMC Veterans Affairs Medical Center Philadelphia Pennsylvania USA"},{"name":"CReATE Motion Center, CMC Veterans Affairs Medical Center Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-6042","authenticated-orcid":false,"given":"Nadeen O.","family":"Chahine","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Columbia University New York New York USA"},{"name":"Department of Biomedical Engineering Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-847X","authenticated-orcid":false,"given":"Lara","family":"Silverman","sequence":"additional","affiliation":[{"name":"LIS Bioconsulting, LLC Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-1485","authenticated-orcid":false,"given":"Dmitriy","family":"Sheyn","sequence":"additional","affiliation":[{"name":"Orthopedic Stem Cell Research Lab, Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Board of Governors Regenerative Medicine Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Department of Orthopedics, Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Department of Surgery, Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Department of Biomedical Sciences, Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00098-X"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2014.01.006"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-025-00472-7"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113143"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00568-w"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2025.124107"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2025.06.003"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.13"},{"key":"e_1_2_14_10_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202502354","article-title":"Cell and Hydrogel\u2010Integrated Therapies for Intervertebral Disc Regeneration","volume":"15","author":"Tang Y.","year":"2025","journal-title":"Advanced Healthcare Materials"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1417600"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123895"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.06.012"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144889"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1111356"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e31162"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2017.02.002"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2192568220963058"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109018"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.01.100"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34898"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08332-w"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.592118"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.968862"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37360"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.70025"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.1191"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00397-7"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-022-00245-4"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000146101.53784.b1"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000206358.66412.7b"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2111"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.03.013"},{"key":"e_1_2_14_34_1","unstructured":"VIVEX Biologics I (2026)\u201cClinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease (RESTORE) \u201d."},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9040148"},{"key":"e_1_2_14_36_1","unstructured":"Therapies B (2025)\u201cA Single Dose of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD) \u201d."},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2025.03.015"},{"key":"e_1_2_14_38_1","unstructured":"Celular RdT (2024)\u201cTreatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) (Disc_allo) \u201d."},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8671482"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108893"},{"key":"e_1_2_14_41_1","unstructured":"Shanghai General Hospital Shanghai Jiao Tong University School of Medicine (2020)\u201cHuman Umbilical Cord Mesenchymal Stem Cells for the Treatment of Lumbar Disc Degeneration Disease \u201d."},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1029"},{"key":"e_1_2_14_43_1","unstructured":"Center UHCM (2022)\u201cMesenchymal Stem Cells for Lumbar Degenerative Disc Disease \u201d."},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2024.7.E865"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137306"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216024"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02313-9"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.02.045"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202403742"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/19373341251359106"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2025.12.004"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2019.08.006"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34582-6"},{"key":"e_1_2_14_54_1","unstructured":"VIVEX Biologics I (2025)\u201cASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP a Supplement for Degenerated Intervertebral Discs (ASCEND) \u201d."},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1643222"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7564159"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1601154"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.933901"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.4118"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1685975"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3908"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom16010170"},{"key":"e_1_2_14_63_1","doi-asserted-by":"crossref","unstructured":"M.Tsingas K.Tsingas W.Zhang A. R.Goldman andM. V.Risbud \u201cLactate Metabolic Coupling Between the Endplates and Nucleus Pulposus via MCT1 Is Essential for Intervertebral Disc Health \u201d(2025) bioRxiv.","DOI":"10.1101\/2025.02.24.640004"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199104000-00010"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300858"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC\/2008\/24\/3-4\/E20"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S251495"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1186"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v13.i12.1881"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00090"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23061"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.750668"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02146615"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-025-02003-w"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110844"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S382069"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.103054"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022495118"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10249009"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20994"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.32401"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg7020"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126612"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00372-2"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802725RRR"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00300.2014"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-025-00402-7"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01546-6"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002201R"},{"key":"e_1_2_14_90_1","first-page":"1","article-title":"An Integrated Multi\u2010Algorithm Analysis to Decipher Senescence and Metabolic Characteristics in Nucleus Pulposus Cells During Disc Degeneration","author":"Liao Z.","year":"2025","journal-title":"Geroscience"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-025-00416-1"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081257"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr1719"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1732"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2275"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.02.034"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2636"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38075"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3443"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073993"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-78675-x"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103631"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31815b9850"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23628"},{"key":"e_1_2_14_105_1","first-page":"353","article-title":"Selection of the Optimal Puncture Needle for Induction of a Rat Intervertebral Disc Degeneration Model","volume":"22","author":"Qian J.","year":"2019","journal-title":"Pain Physician"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.5.SPINE10811"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12168244"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2024.10.002"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12168244"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2025.114691"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31826b71f4"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300227R"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.11.019"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1014"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300227R"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1246-x"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3931"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31824ee8f7"},{"key":"e_1_2_14_119_1","doi-asserted-by":"crossref","unstructured":"K. G.Burt M. K. M.Kim D. C.Viola et\u00a0al. \u201cNuclear Factor Kappa B Over\u2010Activation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration \u201d(2023) bioRxiv.","DOI":"10.1101\/2023.08.07.552274"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.70143"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402658R"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0205"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2473"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.108"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.168534"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v2.i2.34"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010088"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0876-y"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00392"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0753-5"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.03.027"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0840-2"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2017.03.003"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-018-0953-9"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200701818595"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23350"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0488"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.94"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-010-1662-9"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0623-7"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.10.59"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000045055.63901.A9"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3838"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01176.x"},{"key":"e_1_2_14_146_1","article-title":"Single\u2010Cell Microgel Encapsulation Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Treating Intervertebral Disc Degeneration via Inhibiting Pyroptosis","volume":"7","author":"Huang G.","year":"2024","journal-title":"Research (Wash D C)"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2009.08.003"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24392"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42151-3"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10692-5"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21805"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.008128"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.10.016"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.202983"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.303504"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.014"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2018.11.018"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.192724"},{"key":"e_1_2_14_159_1","first-page":"227","article-title":"Osmoregulatory Function of Large Vacuoles Found in Notochordal Cells of the Intervertebral Disc Running Title: An Osmoregulatory Vacuole","volume":"4","author":"Hunter C. J.","year":"2007","journal-title":"Molecular & Cellular Biomechanics"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51221"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3344"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21534"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v032a11"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0309"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0251-y"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.02.001"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122562"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.022"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21483"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035221113959"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504347"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.70043"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02362-1"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-024-08163-3"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v041a07"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50045-1"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04514"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-025-00843-4"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn404945r"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12305"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.70149"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2023.9518"},{"key":"e_1_2_14_183_1","first-page":"466","article-title":"A Human Progenitor Cell\u2010Based Tissue Engineered Intervertebral Disc","volume":"32","author":"Frehner S. S.","year":"2025","journal-title":"Tissue Engineering. Part A"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001021R"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.03.024"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.005"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.11.007"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1562412"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1003"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2019.107447"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123120"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1425529"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300348RR"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-022-01061-x"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.5.1399"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00331"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007566108"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.70005"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf6927"},{"key":"e_1_2_14_200_1","doi-asserted-by":"crossref","unstructured":"J.Warin E.Balissat P.Colombier et\u00a0al. \u201cSpatiotemporal Cellular Dynamics of the Notochord Shape Intervertebral Disc Morphogenesis in the Mouse Embryo Through Apoptosis and Proliferation \u201d(2026) bioRxiv.","DOI":"10.1002\/dvdy.70119"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110768"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3548"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101149R"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1627149"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20567"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10091049"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S565510"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.03.020"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1143157"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1669399"},{"key":"e_1_2_14_211_1","article-title":"iPSC Modification Strategies to Induce Immune Tolerance","volume":"4","author":"Hong Z.","year":"2025","journal-title":"Lifestyle Medicine"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404496"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14161248"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199904150-00005"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1992.0115"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(97)00069-9"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000192236.92867.15"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100150224"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199406000-00011"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semss.2011.11.009"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.07.025"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.03.041"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.10.002"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118828"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.09.018"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0103"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303326"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10040269"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2013.0498"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2018.0170"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328210387174"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01554-4"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300180"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100365"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.04.019"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027170"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2016.12.004"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.03.029"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.03.006"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.102907"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10010062"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03021-5"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.11.017"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.08.023"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122509"},{"key":"e_1_2_14_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100731"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-019-0216-x"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.976706"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101252"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102630"},{"key":"e_1_2_14_252_1","doi-asserted-by":"publisher","DOI":"10.3389\/frsfm.2022.1101680"},{"key":"e_1_2_14_253_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202404963"},{"key":"e_1_2_14_254_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c11710"},{"key":"e_1_2_14_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21867"},{"key":"e_1_2_14_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202404732"},{"key":"e_1_2_14_257_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00579"},{"key":"e_1_2_14_258_1","first-page":"57953","article-title":"Living and Injectable Porous Hydrogel Microspheres Promoting Inflammation Modulation and Extracellular Matrix Remodeling for Intervertebral Disc Regeneration","volume":"17","author":"Zhang X.","year":"2025","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_14_259_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5c00345"},{"key":"e_1_2_14_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.02.016"},{"key":"e_1_2_14_261_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB01505G"},{"key":"e_1_2_14_262_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c18801"},{"key":"e_1_2_14_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.12.029"},{"key":"e_1_2_14_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.168613"},{"key":"e_1_2_14_265_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-024-3153-8"},{"key":"e_1_2_14_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.07.008"},{"key":"e_1_2_14_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120193"},{"key":"e_1_2_14_268_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx2768"},{"key":"e_1_2_14_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.175509"},{"key":"e_1_2_14_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.175112"},{"key":"e_1_2_14_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2026.115715"},{"key":"e_1_2_14_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.103087"},{"key":"e_1_2_14_273_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202514952"},{"key":"e_1_2_14_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2026.02.030"},{"key":"e_1_2_14_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2026.116123"},{"key":"e_1_2_14_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.173293"},{"key":"e_1_2_14_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2026.112744"},{"key":"e_1_2_14_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2017.01.003"},{"key":"e_1_2_14_279_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01567-w"},{"key":"e_1_2_14_280_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31172-4"},{"key":"e_1_2_14_281_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.780749"},{"key":"e_1_2_14_282_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23715"},{"key":"e_1_2_14_283_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64940"},{"key":"e_1_2_14_284_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301217R"}],"container-title":["JOR SPINE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsp2.70207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jsp2.70207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsp2.70207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:17:51Z","timestamp":1790306271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jsp2.70207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":283,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jsp2.70207"],"URL":"https:\/\/doi.org\/10.1002\/jsp2.70207","archive":["Portico"],"relation":{},"ISSN":["2572-1143","2572-1143"],"issn-type":[{"value":"2572-1143","type":"print"},{"value":"2572-1143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70207"}}