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Binary mixtures of <jats:italic>n<\/jats:italic>\u2010hexane and alcohol as well as pure alcohols (ethanol or 2\u2010propanol) were used as eluents. The enantiomer elution order was monitored by chiroptical detectors based on on\u2010line optical rotation and circular dichroism measurements. For some of the compounds studied very high enantioseparation factor values (\u03b1 &gt; 7) on Chiralcel OJ CSP were observed. In order to study the chiroptical characteristics of the two most biologically active compounds, chromatographic resolutions were carried out on a semipreparative scale. Assignment of the absolute configuration was empirically established by comparing the CD spectra of the separated enantiomers with those obtained from the enantiomers of Miconazole.<\/jats:p>","DOI":"10.1002\/jssc.200400102","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T05:46:41Z","timestamp":1114580801000},"page":"627-634","source":"Crossref","is-referenced-by-count":23,"title":["Comparative study between the polysaccharide\u2010based Chiralcel OJ and Chiralcel OD CSPs in chromatographic enantioseparation of imidazole analogues of Fluoxetine and Miconazole"],"prefix":"10.1002","volume":"28","author":[{"given":"Roberto","family":"Cirilli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosella","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Gallinella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"La Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"La Regina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romano","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,27]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"FDA Policy Statements for the Development of New Stereoisomeric Drugs. 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