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Those analogues of fadrozole constitute new potent nonsteroidal inhibitors of aromatase (P450 arom). The separations were made using normal phase methodology with a mobile phase consisting of <jats:italic>n<\/jats:italic>\u2010hexane\u2010alcohol (ethanol, 1\u2010propanol, or 2\u2010propanol) in various proportions, and a silica\u2010based cellulose tris\u20103,5\u2010dimethylphenylcarbamate (Chiralcel OD\u2010H), or tris\u2010methylbenzoate (Chiralcel OJ). The effects of concentration of various aliphatic alcohols in the mobile phase were studied. A better separation was achieved on cellulose carbamate phase compared with the cellulose ester phase. The effects of structural features of the solutes along with the temperature of the column on the discrimination between the enantiomers were examined. 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