{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:26:38Z","timestamp":1768350398227,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T00:00:00Z","timestamp":1109548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The static headspace technique is the most common approach to residual solvent analysis in pharmaceutical and environmental matrices. This paper presents an alternative tool where the volatile impurities are released from the matrix by working directly on a small amount of sample at a high equilibration temperature: the so\u2010called Full Evaporation Technique (FET). The capability of this method was evaluated on a mixture of nine solvents, which belong to Class 3 in the classification of the European Pharmacopoeia Agency for residual solvents, at various levels of concentration: ethanol, acetone, 2\u2010propanol, methyl acetate, 2\u2010butanone, ethyl acetate, tetrahydrofuran, 2\u2010methyl\u20101\u2010propanol, 1\u2010butanol. Data on linearity, accuracy, precision and sensitivity are reported. Use of an internal standard proved to be necessary when using such a method. The method is then successfully applied to the analysis of solvent traces in permethylated \u03b2\u2010cyclodextrin.<\/jats:p>","DOI":"10.1002\/jssc.200401851","type":"journal-article","created":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T04:47:18Z","timestamp":1109566038000},"page":"380-386","source":"Crossref","is-referenced-by-count":20,"title":["The full evaporation technique: A promising alternative for residual solvents analysis in solid samples"],"prefix":"10.1002","volume":"28","author":[{"given":"Audrey","family":"Brault","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Agasse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Cardinael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Combret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,28]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use ICH Harmonised Tripartite Guideline Q3C Impurities: Guideline for Residual Solvents (Brussels July 1997)."},{"key":"e_1_2_1_3_2","unstructured":"European Pharmacopoeia 2000. Identification and control of residual solvents. In: European Pharmacopoeia Supplement 2000 European Department for the Quality of Medicines within the Council of Europe Strasbourg Section 2.4.24 32\u201336."},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","unstructured":"J.Szejtli Cyclodextrin Technology Kluwer Academic Publisher Dordrecht 1988.","DOI":"10.1007\/978-94-015-7797-7"},{"key":"e_1_2_1_5_2","unstructured":"B.Kolb L.Ettre Static Headspace\u2010Gas Chromatography Theory and Practice Wiley\u2010VCH Weinheim 1997."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)89072-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274577"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac970040u"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20010201)24:2<109::AID-JSSC109>3.0.CO;2-T"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2670(93)80390-7"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac951084a"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/34.7.314"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00611-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/15320389709383579","volume":"6","author":"Stuart J.D.","year":"1997","journal-title":"J. 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