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The effect of mobile phase variables such as methanol content, ionic strength, and pH on their chromatographic behavior was investigated. The retention mechanism of basic drugs on the stationary phase was elucidated. The results indicate that both hydrophobic and cation\u2010exchange interactions contribute to solute retention under most chromatographic conditions. The inherent Br\u00f6nsted\u2010acid sites and also the adsorbed Lewis base anionic buffer constituents on accessible ZM surface Lewis acid sites play a role in the retention of ionized solutes by cation\u2010exchange interaction. However, especially at high mobile phase pH, the retention of basic drugs depends mainly on hydrophobic interactions between solutes and support. Separations of the basic drugs on the C<jats:sub>18<\/jats:sub>PZM phase by a predominantly reversed\u2010phase retention mode were very promising. The mixed\u2010mode retention feature on this phase, as a result of the adsorbed Lewis base anionic buffer constituents acting as sites for cation\u2010exchange, could also be very useful, <jats:italic>e.g.<\/jats:italic> for enhancing the chromatographic selectivity of such analytes. The C<jats:sub>18<\/jats:sub>PZM seems to be an excellent alternative to silica\u2010based reversed\u2010phase stationary phase for the separation of strongly basic solutes.<\/jats:p>","DOI":"10.1002\/jssc.200500042","type":"journal-article","created":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T06:17:19Z","timestamp":1124086639000},"page":"1577-1586","source":"Crossref","is-referenced-by-count":14,"title":["High\u2010performance liquid chromatography of some basic drugs on a <i>n<\/i>\u2010octadecylphosphonic acid modified magnesia\u2010zirconia stationary phase"],"prefix":"10.1002","volume":"28","author":[{"given":"Hai\u2010Bo","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Qi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Lu","family":"Da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Xiong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"440","volume":"17","author":"McCalley D.V.","year":"1999","journal-title":"LC\u2010GC"},{"key":"e_1_2_1_3_2","first-page":"494","volume":"6","author":"Stadalius M.A.","year":"1988","journal-title":"LC\u2010GC"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200290007"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00811-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/25.11.489"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00479-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"L.R.Snyder J.J.Kirkland J.L.Glajch Practical HPLC Method Development 2nd ed. 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