{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:31:57Z","timestamp":1760887917955,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T00:00:00Z","timestamp":1152057600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several racemic acidic compounds of pharmaceutical and environmental interest have been separated into their enantiomers by nano\u2010liquid chromatography (nano\u2010LC) employing a<jats:italic> tert<\/jats:italic>\u2010butylbenzoylated tartardiamide chiral stationary phase (CHI\u2010TBB). CHI\u2010TBB was packed into a fused silica capillary of 100 \u03bcm id and retained by two frits made with a heated wire; detection was on\u2010column at a window (about 0.5 cm) prepared by removing the polyimide layer. The normal phase mode was selected for eluting the studied acidic compounds and therefore<jats:italic> n<\/jats:italic>\u2010hexane\/2\u2010propanol\/acetic acid (89\/10\/1, v\/v\/v) was used as mobile phase. Working at a flow rate of 220 nL\/min a good resolution was obtained for mecoprop, dichlorprop, diclofop, fenoxaprop (herbicides) and for DF 1738Y, DF 1770Y, DF 2008Y (drugs under evaluation). In order to optimize the chiral resolution we modified the polarity of the mobile phase by adding several polar additives such as ethyl acetate, dichloromethane, <jats:italic>tert<\/jats:italic>\u2010butyl methyl ether. Better results were obtained for some herbicides on working with 2\u2010propanol\/CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub>\/<jats:italic>n<\/jats:italic>\u2010hexane\/acetic acid (8\/4\/87\/1, v\/v\/v\/v). The influence of the capillary temperature on chiral resolution was studied for two herbicides with different chemical structures, namely mecoprop and haloxyfop in the temperature range between 10 and 40\u00b0C and with<jats:italic> n<\/jats:italic>\u2010hexane\/2\u2010propanol\/1% acetic acid (89\/10\/1, v\/v\/v) as the mobile phase. Linear correlation of ln<jats:italic> k vs<\/jats:italic> 1\/<jats:italic>T <\/jats:italic>and ln \u03b1 <jats:italic>vs<\/jats:italic> 1\/<jats:italic>T<\/jats:italic> was observed; \u0394<jats:italic>H<\/jats:italic>\u00b0 values were negative, demonstrating that retention of analytes was an exothermic process. A decrease in resolution was observed with rising temperature, showing that enantioresolution was mainly influenced by selectivity factors.<\/jats:p>","DOI":"10.1002\/jssc.200600052","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T00:28:15Z","timestamp":1152145695000},"page":"1423-1431","source":"Crossref","is-referenced-by-count":15,"title":["Use of <i>tert<\/i>\u2010butylbenzoylated tartardiamide chiral stationary phase for the enantiomeric resolution of acidic compounds by nano\u2010liquid chromatography"],"prefix":"10.1002","volume":"29","author":[{"given":"Salvatore","family":"Fanali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"D'Orazio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Gubitz G. Schmid M. G. in: Gubitz G. Schmid M. G. (ed.) Chiral Separation Principles in Chiral Separations Methods and Protocols Humana Press Totowa New Jersey 2003 p.\u20091."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00202-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0801(199912)13:8<531::AID-BMC921>3.0.CO;2-Q"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.10.090"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1520-636X(2000)12:8<606::AID-CHIR2>3.0.CO;2-H"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00531-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.04.060"},{"key":"e_1_2_1_9_2","unstructured":"Chankvetadze B. Capillary Electrophoresis in Chiral Analysis John Wiley & Sons Chichester 1997 pp. 1\u2013554."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200109)22:15<3131::AID-ELPS3131>3.0.CO;2-S"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00096-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240150216"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200202)23:3<477::AID-ELPS477>3.0.CO;2-L"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00119a003"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac020240s"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00388a026"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00169a032"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530070411"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(96)00153-7"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1999)11:5\/6<420::AID-CHIR12>3.0.CO;2-V"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00168a006"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00422-6"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200202)23:3<486::AID-ELPS486>3.0.CO;2-L"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.10120"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200401819"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200500142"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","unstructured":"Snyder L. R. Kirkland J. J. Glajch J. L. Practical HPLC Method Development J. Wiley & Sons Inc. New York USA 1997 second edition pp. 266\u2013289.","DOI":"10.1002\/9781118592014"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)80383-8"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)80371-4"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00505-7"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-005-0560-5"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)00244-3"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.200600052","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.200600052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:58:25Z","timestamp":1760871505000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.200600052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1002\/jssc.200600052"],"URL":"https:\/\/doi.org\/10.1002\/jssc.200600052","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"type":"print","value":"1615-9306"},{"type":"electronic","value":"1615-9314"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}