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The separation, resolution, and elution order of the investigated compounds were compared on both immobilized and coated cellulose tris(3,5\u2010dimethylphenylcarbamate) CSPs (Chiralpak IB and Chiralcel OD, respectively) using a mixture of<jats:italic> n<\/jats:italic>\u2010hexane\/2\u2010propanol (90:10 v\/v) as mobile phase with different flow\u2010rates and fixed UV detection at 254 nm. The effect of the immobilization of the cellulose tris\u2010(3,5\u2010dimethylphenylcarbamate) CSP on silica (Chiralpak IB) on the chiral recognition ability was noted as the coated phase (Chiralcel OD) possesses a higher resolving power in some cases than the immobilized one (Chiralpak IB). However, a few racemates, which were not or poorly resolved on the immobilized Chiralpak IB or the coated Chiralcel OD when using standard solvents were most efficiently resolved on the immobilized Chiralpak IB upon using nonstandard solvents. Furthermore, the immobilized phase withstands the nonstandard (prohibited) HPLC solvents mentioned previously when used as eluents or as a dissolving agent for the analyte itself. An example of inversion or apparent inversion of elution order on Chiralpak IB is reported. The direct analysis of a spiked plasma sample extracted using DCM on Chiralpak IB is also shown.<\/jats:p>","DOI":"10.1002\/jssc.200600357","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T09:53:40Z","timestamp":1175162020000},"page":"1019-1028","source":"Crossref","is-referenced-by-count":19,"title":["Exploring solvent versatility in immobilized cellulose\u2010based chiral stationary phase for the enantioselective liquid chromatographic resolution of racemates"],"prefix":"10.1002","volume":"30","author":[{"given":"Ashraf","family":"Ghanem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980504)37:8<1020::AID-ANIE1020>3.0.CO;2-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.09.081"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)00958-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.10195"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200400102"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03407-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0693823"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200590003"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)93965-7"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)90318-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(91)85020-G"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)85104-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac961241l"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)81470-9"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)00803-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1986.1237"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1988.1125"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)80539-3"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00531-8"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.05.011"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)01104-X"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.10.003"},{"key":"e_1_2_1_24_2","unstructured":"Francotte E. 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