{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:04:53Z","timestamp":1761743093678,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T00:00:00Z","timestamp":1209513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dibenzo[<jats:italic>a<\/jats:italic>,<jats:italic>c<\/jats:italic>]cyclooctadiene lignans of<jats:italic> Schisandra chinensis<\/jats:italic> Baill are well known because of their hepatoprotective activity, antioxidant activity, and anticancer effect. For the isolation of the dibenzo[<jats:italic>a<\/jats:italic>,<jats:italic>c<\/jats:italic>]cyclooctadiene lignans of<jats:italic> Schisandra chinensis<\/jats:italic> Baill two extraction methods were used: modified\u2010ultrasonic extraction and supercritical fluid extraction. A specific and fast analytical method for structure identification is established for quality control because structure elucidation could be accomplished by means of liquid chromatography\u2013mass spectrometry (LC\u2013MS) technologies. The separation and identification of the compounds were completed by: (i) a water\u2013acetonitrile gradient system using a C18 reversed\u2010phase column; (ii) UV detection at 225 nm; (iii) MS\/MS experiments with electrospray ionization interface (ESI) ion trap mass spectrometry in the positive mode. Normalized collision energy was used to obtain fragment ions of structural relevance in the LC\u2013MS\/MS. These results provided a reliable LC\u2013MS\/MS method for the determination of the dibenzo[<jats:italic>a<\/jats:italic>,<jats:italic>c<\/jats:italic>]cyclooctadiene lignans from<jats:italic> Schisandra chinensis<\/jats:italic> Baill. Finally, we also detected 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl (DPPH) scavenging effects (%) of the modified\u2010ultrasonic and supercritical fluid extracts of <jats:italic>Schisandra chinensis <\/jats:italic>Baill compared with 6\u2010hydroxy\u20102,5,7,8\u2010tetramethylchroman\u20102\u2010carboxylic acid (Trolox). The antioxidant activities of the modified\u2010ultrasonic and supercritical fluid extracts were lower than that of trolox.<\/jats:p>","DOI":"10.1002\/jssc.200700443","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T07:50:29Z","timestamp":1209541829000},"page":"1322-1332","source":"Crossref","is-referenced-by-count":22,"title":["High throughput screening and antioxidant assay of dibenzo[<i>a<\/i>,<i>c<\/i>]cyclooctadiene lignans in modified\u2010ultrasonic and supercritical fluid extracts of <i>Schisandra chinensis<\/i> Baill by liquid chromatography\u2013mass spectrometry and a free radical\u2010scavenging method"],"prefix":"10.1002","volume":"31","author":[{"given":"Ming\u2010Chih","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih\u2010Cherng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Lin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1051\/analusis:2000280885"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.59.3.0016"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20089"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.06.036"},{"key":"e_1_2_1_6_2","first-page":"63","volume":"29","author":"You J. 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