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The chromatographic resolution of its chiral intermediates including related substances in the total synthesis of armodafinil was studied on polysaccharide\u2010based stationary phases,<jats:italic> viz.<\/jats:italic> cellulose tris\u2010(3,5\u2010dimethylphenylcarbamate) (Chiralcel OD\u2010H) and amylose tris\u2010(3,5\u2010dimethylphenylcarbamate) (Chiralpak AD\u2010H) by HPLC. The effects of 1\u2010propanol, 2\u2010propanol, ethanol, and trifluoroacetic acid added to the mobile phase and of column temperature on resolution were studied. A good separation was achieved on cellulose\u2010based Chiralcel OD\u2010H column compared to amylose\u2010based Chiralpak AD\u2010H. The effects of structural features of the solutes and solvents on discrimination between the enantiomers were examined. Baseline separation with <jats:italic>R<\/jats:italic><jats:sub>s<\/jats:sub> &gt;1.38 was obtained using a mobile phase containing <jats:italic>n<\/jats:italic>\u2010hexane\u2013ethanol\u2013TFA (75:25:0.15 v\/v\/v). Detection was carried out at 225 nm with photodiode array detector while identification of enantiomers was accomplished by a polarimetric detector connected in series. The method was found to be suitable not only for process development of armodafinil but also for determination of the enantiomeric purity of bulk drugs and pharmaceuticals.<\/jats:p>","DOI":"10.1002\/jssc.200700545","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T08:33:10Z","timestamp":1207038790000},"page":"981-989","source":"Crossref","is-referenced-by-count":13,"title":["Enantioselective HPLC resolution of synthetic intermediates of armodafinil and related substances"],"prefix":"10.1002","volume":"31","author":[{"given":"Ramisetti","family":"Nageswara Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhananjay D.","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali V. 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