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Antibiotic residues constitute a risk to human health, since they can cause allergic reactions in hypersensitive individuals or they may lead to the appearance of drug\u2010resistant bacteria. Analysis of these residues plays a key role in ensuring food safety. Regulatory agencies in the European Union and in other countries have established maximum residue limits and requirements concerning the performance of analytical methods and the interpretation of the results. This review describes the state of the art in the analytical strategies concerning the multi\u2010class as well as the multi\u2010residue analysis of antibiotics in milk. Since milk is a complex matrix due to its high protein and fat content, which often interfere in analytical procedures, special focus has been placed on sample preparation: extraction and clean\u2010up. Confirmation of antibiotic residues according to European Decision 657\/2002\/EC has been also discussed.<\/jats:p>","DOI":"10.1002\/jssc.200700647","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T03:47:07Z","timestamp":1215661627000},"page":"2068-2090","source":"Crossref","is-referenced-by-count":83,"title":["Multi\u2010residue methods for confirmatory determination of antibiotics in milk"],"prefix":"10.1002","volume":"31","author":[{"given":"Victoria","family":"Samanidou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Nisyriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,10]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Council Regulation (EEC) 2377\/90 (OJ L224 p1 18\/08\/90) of 26 June 1990 establishing Community procedures for fixing maximum limits for veterinary drug residues in foodstuffs of animal origin."},{"key":"e_1_2_1_3_2","unstructured":"Council Directive (EEC) 96\/23\/EC (OJ L125 p10) of 29 April 1996 on measures to monitor certain substances and residues thereof in live animals and animal products and repealing Directives 85\/358\/EEC and 86\/469\/EEC and Decisions 89\/187\/EEC and 91\/ 664\/EEC."},{"key":"e_1_2_1_4_2","unstructured":"Joint FAO\/WHO Expert Consultation on Food Additives (JECFA); Evaluation of Certain Food Additives and Contaminants \u2013 Forty\u2010forth report of the Joint FAO\/WHO Expert Consultation on Food Additives 1995."},{"key":"e_1_2_1_5_2","unstructured":"Food and Drug Administration (FDA); Food Additives: Threshold of Regulation for Substances Used in Food Contact Articles; Final Rule 21CFR Part\u20095 et al. 1995."},{"key":"e_1_2_1_6_2","unstructured":"European Commission 2002\/657\/EC: Commission Decision of 12 August 2002 implementing Council Directive 96\/23\/EC concerning the performance of analytical methods and the interpretation of results Off. 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