{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:33:58Z","timestamp":1761323638573,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T00:00:00Z","timestamp":1251676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["CTM2008-06847-C02-01 and CTQ2008-0825"],"award-info":[{"award-number":["CTM2008-06847-C02-01 and CTQ2008-0825"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present paper, we describe the synthesis of a cephalexin (CFX) molecularly imprinted polymer (MIP), the direct application of the MIP to SPE for the determination of CFX (which is a \u03b2\u2010lactam antibiotic) in human urine and the use of the MIP in a tandem SPE system to determine CFX in river water. The molecularly imprinted polymers (MIP) showed cross\u2010selectivity for amoxicillin (AMX; also a \u03b2\u2010lactam antibiotic). This allowed both CFX and AMX to be quantified in acidified human urine, with recoveries of 78 and 60% for CFX and AMX, respectively, when the urine samples were spiked with CFX and AMX at 4 mg\/L. These analyses were facile because the molecularly imprinted solid\u2010phase extraction (MISPE) extracts were clear compared to the nonpurified samples. In order to increase the sample volume for river water analyses, a tandem SPE system incorporating a commercially available sorbent was implemented. With this set\u2010up, CFX was determined with recoveries in excess of 50% when 200 mL of acidified river water samples spiked at 10 \u03bcg\/L with CFX were percolated through the tandem system.<\/jats:p>","DOI":"10.1002\/jssc.200900268","type":"journal-article","created":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T10:37:39Z","timestamp":1251715059000},"page":"3319-3326","source":"Crossref","is-referenced-by-count":29,"title":["Molecularly imprinted solid\u2010phase extraction of cephalexin from water\u2010based matrices"],"prefix":"10.1002","volume":"32","author":[{"given":"Antoni","family":"Beltran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Fontanals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa M.","family":"Marc\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A. 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