{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:41:44Z","timestamp":1791135704590,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T00:00:00Z","timestamp":1276473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2007\/00465-2"],"award-info":[{"award-number":["2007\/00465-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2007\/01420-2"],"award-info":[{"award-number":["2007\/01420-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Bournemouth, UK"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A number of fatty acid ethyl esters (FAEEs) have recently been detected in meconium samples. Several of these FAEEs have been evaluated as possible biomarkers for <jats:italic>in utero<\/jats:italic> ethanol exposure<jats:italic>.<\/jats:italic> In the present study, a method was optimized and validated for the simultaneous determination of eight FAEEs (ethyl laurate, ethyl myristate, ethyl palmitate, ethyl palmitoleate, ethyl stearate, ethyl oleate, ethyl linoleate and ethyl arachidonate) in meconium samples. FAEEs were extracted by headspace solid\u2010phase microextraction. Analyte detection and quantification were carried out using GC\u2010MS operated in chemical ionization mode. The corresponding D5\u2010ethyl esters were synthesized and used as internal standards. The LOQ and LOD for each analyte were &lt;150 and &lt;100\u2009ng\/g, respectively. The method showed good linearity (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>&gt;0.98) in the concentration range studied (LOQ \u2013 2000\u2009ng\/g). The intra\u2010 and interday imprecision, given by the RSD of the method, was lower than 15% for all FAEEs studied. The validated method was applied to 63 authentic specimens. FAEEs could be detected in alcohol\u2010exposed newborns (&gt;600\u2009ng\/g cumulative concentration). Interestingly, FAEEs could also be detected in some non\u2010exposed newborns, although the concentrations were much lower than those measured in exposed cases.<\/jats:p>","DOI":"10.1002\/jssc.201000118","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T12:11:01Z","timestamp":1276517461000},"page":"2115-2122","source":"Crossref","is-referenced-by-count":26,"title":["Determination of eight fatty acid ethyl esters in meconium samples by headspace solid\u2010phase microextraction and gas chromatography\u2013mass spectrometry"],"prefix":"10.1002","volume":"33","author":[{"given":"Marli","family":"Roehsig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Mendes Louzada","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidnei","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna Maria","family":"de Albuquerque Diniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Yonamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200306000-00004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318167cfe5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00442-6"},{"key":"e_1_2_6_5_2","first-page":"799","volume-title":"Drug Abuse Handbook","author":"Huestis M. 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