{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:42:53Z","timestamp":1777470173153,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T00:00:00Z","timestamp":1289865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A sensitive and reproducible stir bar sorptive extraction and HPLC\u2010UV detection method was used for the therapeutic drug monitoring of chlorpromazine and trifluoperazine in human serum. The separation was achieved using a C<jats:sub>18<\/jats:sub> column. The mobile phase consisted of methanol\/sodium acetate buffer (pH 4.1; 0.1 M) (95:5, v\/v) including 0.5% triethylamine. This miniaturized method can result in faster analysis, lower solvent consumption and less workload <jats:italic>per<\/jats:italic> sample while maintaining or even improving sensitivity. In the second part, stir bar sorptive extraction\/HPLC\u2010UV method was optimized by a chemometrics approach. An experimental design was therefore used to evaluate the statistically influential and\/or interacting factors, among those described in the literature, and to find the best extraction and desorption conditions. Optimal sample volume of 1\u2009mL, extraction time of 24\u2009min at 31\u00b0C with pH 8.1 were obtained in a screening 2<jats:sup>5<\/jats:sup> half fractional factorial design followed by a Box\u2013Behnken design. For the desorption conditions, a Box\u2013Behnken design showed that the best conditions were 150\u2009\u03bcL mobile phase for 20\u2009min at 50\u00b0C. The optimized method was repeatable (CV&lt;10%, linear (LOQ\u2010500\u2009ng\/mL)), with the LOQs equal to 0.7 and 1.5\u2009ng\/mL for chlorpromazine and trifluoperazine, respectively.<\/jats:p>","DOI":"10.1002\/jssc.201000649","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T06:12:27Z","timestamp":1289887947000},"page":"90-97","source":"Crossref","is-referenced-by-count":31,"title":["A simple and reliable stir bar sorptive extraction\u2010liquid chromatography procedure for the determination of chlorpromazine and trifluoperazine in human serum using experimental design methodology"],"prefix":"10.1002","volume":"34","author":[{"given":"Shaghayegh","family":"Bazhdanzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Talebpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noushin","family":"Adib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan Y.","family":"Aboul\u2010Enein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408340701804343"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00467-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.997"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.12.007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.04.004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.05.015"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.05.067"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500098"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11419-007-0020-z"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(03)00680-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.09.026"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-667X(1999)11:10<737::AID-MCS7>3.0.CO;2-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-008-0687-2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.03.119"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.03.036"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.11.042"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.11.042"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.08.025"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2008.07.032"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2005.12.028"},{"key":"e_1_2_6_22_2","volume-title":"Response Surface Methodology: Process and Product Optimization Using Designed Experiments","author":"Myers R. 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