{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:10:53Z","timestamp":1790392253386,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T00:00:00Z","timestamp":1305849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["20977058"],"award-info":[{"award-number":["20977058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["50979049"],"award-info":[{"award-number":["50979049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011329","name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology","doi-asserted-by":"crossref","award":["KF2008-05"],"award-info":[{"award-number":["KF2008-05"]}],"id":[{"id":"10.13039\/501100011329","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Environmental Protection, Hubei Province, China","award":["2008HB08"],"award-info":[{"award-number":["2008HB08"]}]},{"DOI":"10.13039\/501100002861","name":"China Three Gorges University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002861","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Effects of mobile\u2010phase variations on the chromatographic separation on amino\u2010bonded silica column in hydrophilic interaction chromatography (HILIC) were investigated for four zwitterionic tetracyclines (TCs): oxytetracycline, doxycycline, chlortetracycline, and tetracycline. A mixed\u2010mode retention mechanism composed of partitioning, adsorption, and ion exchange interactions was proposed for the amino HILIC retention process. Buffer type and pH significantly influenced the retention of TCs, but showed similar separation selectivity for the tested analytes. Experiments varying buffer salt concentration and pH demonstrated the presence of ion exchange interactions in TCs retention. The type and concentration of organic modifier also affected the retention and selectivity of the analytes, providing direct evidence supporting the Alpert retention model for HILIC. The retention time of the analytes increased in the following order of organic modifiers: tetrahydrofuran\u2009&lt;\u2009methanol\u2009&lt;\u2009isopropanol\u2009&lt;\u2009acetonitrile. The linear relationships of log<jats:italic>k<\/jats:italic>\u2032 versus %water (v\/v) curve and log<jats:italic>k<\/jats:italic>\u2032 versus logarithm of %water (v\/v) in the mobile phase indicated that TCs separation on the amino phase was controlled by partitioning and adsorption. The developed method was successfully utilized in the detection of TCs in both river water and wastewater samples using solid\u2010phase extraction (SPE) for sample cleanup.<\/jats:p>","DOI":"10.1002\/jssc.201100130","type":"journal-article","created":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T04:51:57Z","timestamp":1305867117000},"page":"1508-1516","source":"Crossref","is-referenced-by-count":64,"title":["Hydrophilic interaction chromatography separation mechanisms of tetracyclines on amino\u2010bonded silica column"],"prefix":"10.1002","volume":"34","author":[{"given":"Ruiping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.04.013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2006.03.026"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2008.08.027"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2009.12.034"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2009.12.032"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/b820492f"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2005.05.005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2007.01.012"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.07.031"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2007.02.007"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-2635-x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2008.05.006"},{"key":"e_1_2_6_14_2","first-page":"2075","volume":"20","author":"Li R. P.","year":"2008","journal-title":"Prog. Chem."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.01.034"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-005-0546-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2003.09.036"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.03.073"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2008.10.051"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2009.04.042"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.04.042"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)96972-3"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200600199"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.01.075"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800051"},{"key":"e_1_2_6_26_2","first-page":"1508","volume":"18","author":"Li R. P.","year":"2006","journal-title":"Prog. Chem."},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.01.049"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3573"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.12.057"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.07.036"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-007-1754-5"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.12.028"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-003-0139-y"},{"key":"e_1_2_6_34_2","first-page":"840","volume":"37","author":"Zhang Y.","year":"2009","journal-title":"Chinese J. Anal. Chem."},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/15422110701539129"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(04)01149-5"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac020012y"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700624"},{"key":"e_1_2_6_39_2","first-page":"494","volume":"6","author":"Stadalius M. A.","year":"1988","journal-title":"LC\u2010GC"},{"key":"e_1_2_6_40_2","unstructured":"AV 014\u201001 Version V06:2003 Proceedings for the Validation of Test Methods EU and National Reference Laboratory for Residues Berlin2003."},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2007.09.010"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.06.071"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201100130","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201100130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.201100130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:54:22Z","timestamp":1760882062000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.201100130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,20]]},"references-count":41,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/jssc.201100130"],"URL":"https:\/\/doi.org\/10.1002\/jssc.201100130","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,20]]}}}