{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:59:43Z","timestamp":1787313583080,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"16-17","license":[{"start":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T00:00:00Z","timestamp":1307318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science","award":["19590673"],"award-info":[{"award-number":["19590673"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A method coupling spin column extraction with gas chromatography\u2010mass spectrometry was developed for the simultaneous extraction of acidic and basic drugs from urine. Benzodiazepines, local anaesthetics, antidepressants, and barbiturates were used as model drugs. Sample loading, washing, and elution of the target drugs were accomplished by centrifugation of the column. In this study, mixed\u2010mode monolithic silica bonded with a C18 reversed\u2010phase and a strong cation exchange phase was packed in a spin column. The pH of a urine sample (0.2\u2009mL) was adjusted to 3 and the analytes adsorbed onto the column were eluted with 0.1\u2009mL of MeOH containing 2% NH\n                    <jats:sub>3<\/jats:sub>\n                    ; all the tested drugs were simultaneously extracted from urine. The recovery of the tested drugs was 65\u2013123%. Up to a concentration of 2500\u2009ng\/mL of the target drugs in urine, a linear curve was observed (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    &gt;0.996). The intra\u2010 and interday RSDs at three different concentrations in urine were 2.1\u201314.7%. For RSDs lower than 15%, the limits of detection were 1\u201325\u2009ng\/mL. The proposed method was successfully applied for clinical and forensic cases and the results thus obtained were in good agreement with those obtained by conventional methods.\n                  <\/jats:p>","DOI":"10.1002\/jssc.201100165","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T08:27:56Z","timestamp":1307348876000},"page":"2232-2239","source":"Crossref","is-referenced-by-count":14,"title":["Simultaneous extraction of acidic and basic drugs from urine using mixed\u2010mode monolithic silica spin column bonded with octadecyl and cation\u2010exchange group"],"prefix":"10.1002","volume":"34","author":[{"given":"Akira","family":"Namera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/1386207003331355"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00536-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS13211J"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(96)00707-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00265-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/26.6.325"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/31.7.359"},{"key":"e_1_2_6_9_2","first-page":"80","volume":"41","author":"Reddy I. M.","year":"2011","journal-title":"Indian J. Pharmacol."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)01447-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.03.025"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.03.055"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar600034p"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800116"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.08.091"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.03.018"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.07.007"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-009-1204-y"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.12.013"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.56.598"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-4633-4"},{"key":"e_1_2_6_22_2","author":"Namera A.","year":"2011","journal-title":"J. AOAC Int."},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009627216939"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)83287-8"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.2116\/bunsekikagaku.59.213"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201100165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201100165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.201100165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:08:50Z","timestamp":1760879330000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.201100165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,6]]},"references-count":24,"journal-issue":{"issue":"16-17","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1002\/jssc.201100165"],"URL":"https:\/\/doi.org\/10.1002\/jssc.201100165","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,6]]}}}