{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:43:56Z","timestamp":1769129036235,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T00:00:00Z","timestamp":1309737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A precise and reliable method for milk residue analysis regarding five penicillins and three amphenicols by HPLC\u2010diode array detection has been developed herein. The chromatographic separation was performed using a mobile phase of CH<jats:sub>3<\/jats:sub>COONH<jats:sub>4<\/jats:sub> (0.05\u2009M) and ACN delivered by gradient program on a Kinetex<jats:sup>\u2122<\/jats:sup>\u2010C<jats:sub>18<\/jats:sub> core\u2010shell, 2.6\u2009\u03bcm column, starting at a volume ratio of 95:5 and ending at 60:40 after 17\u2009min, remaining stable for 3 more min. A modified matrix solid phase dispersion procedure was applied for the extraction and clean\u2010up procedure of antibiotics using a mixture of Strata by Phenomenex and QuEChERS as a sorbent. The method was validated at the respective 0.5\u00d7 MRL, MRL and 1.5 \u00d7MRL level for each compound. Results were quantitated against the internal standard paracetamol (2\u2009ng\/\u03bcL) according to the matrix\u2010matched approach. The method was validated in line with the EC guidelines as cited in the Decision 2002\/657\/EC. The within\u2010laboratory reproducibility, expressed as a RSD, never exceeded 16%. All decision limit (CC\u03b1) values lay in the range between 35.2 and 56.3\u2009\u03bcg\/kg and the corresponding results for detection capability (CC\u03b2) were 39.9 and 61.9\u2009\u03bcg\/kg. Ruggedness was estimated according to the Youden approach.<\/jats:p>","DOI":"10.1002\/jssc.201100194","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T09:53:15Z","timestamp":1309773195000},"page":"1893-1901","source":"Crossref","is-referenced-by-count":59,"title":["Development and validation according to European Union Decision 2002\/657\/EC of an HPLC\u2010DAD method for milk multi\u2010residue analysis of penicillins and amphenicols based on dispersive extraction by QuEChERS in MSPD format"],"prefix":"10.1002","volume":"34","author":[{"given":"Eftichia G.","family":"Karageorgou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria F.","family":"Samanidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700647"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2006.05.049"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/138527210793351463"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dta.218"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.06.005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2006.10.016"},{"key":"e_1_2_6_8_2","first-page":"243","volume":"2004","author":"Calleri E.","journal-title":"J. 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