{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:06:10Z","timestamp":1771009570256,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T00:00:00Z","timestamp":1312502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A sensitive and rapid derivatization method for the simultaneous determination of 1,3\u2010dichloro\u20102\u2010propanol (1,3\u2010DCP) and 3\u2010chloropropane\u20101,2\u2010diol (3\u2010MCPD) in water samples has been developed. The aim was to research the optimal conditions of the derivatization process for two selected reagents. A central composite design was used to determine the influence of derivatization time, derivatization temperature and reagent volume. A global desirability function was applied for multi\u2010response optimization. The analysis was performed by gas chromatography\u2013mass spectrometry. During the optimization of the extraction procedure, four different types of solid\u2010phase extraction (SPE) columns were tested. It was demonstrated that the Oasis HLB cartridge produced the best recoveries of the target analytes. The pH value and the salinity were investigated using a Doehlert design. The best results for the SPE of both analytes were obtained with 1.5\u2009g of NaCl and pH 6. The proposed method provides high sensitivity, good linearity (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u22650.999) and repeatability (relative standard deviations % between 2.9 and 3.4%). Limits of detection and quantification were in the range of 1.4\u201311.2\u2009ng\/mL and 4.8\u201334.5\u2009ng\/mL, respectively. Recoveries obtained for water samples were ca. 100% for 1,3\u2010DCP and 3\u2010MCPD. The method has been successfully applied to the analysis of different samples including commercially bottled water, an influent and effluent sewage.<\/jats:p>","DOI":"10.1002\/jssc.201100312","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T03:57:08Z","timestamp":1312516628000},"page":"2697-2704","source":"Crossref","is-referenced-by-count":32,"title":["Combined solid\u2010phase extraction and gas chromatography\u2013mass spectrometry used for determination of chloropropanols in water"],"prefix":"10.1002","volume":"34","author":[{"given":"Paula","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Racamonde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia M.","family":"Carro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa A.","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-3177-y"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781444302288.ch12"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.7.2882-2887.2000"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3928-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-005-3139-y"},{"key":"e_1_2_6_7_2","unstructured":"Office of Environmental Health Hazard Assessment (OEHHA).http:\/\/oehha.ca.gov\/prop65\/public_meetings\/sumCIC101110.html."},{"key":"e_1_2_6_8_2","unstructured":"Joint FAO\/WHO Food Standard Programme. \u2018Position paper on Chloropropanols for the Thirty Session of the Codex Committee on Food Additives and Contaminants Part A\u2010Chem\u2019 2001."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/02652030210132391"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2005.09.006"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/02652030110098580","volume":"19","author":"Crewsy C.","year":"2002","journal-title":"Food Add. 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