{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:49Z","timestamp":1788871909033,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:00:00Z","timestamp":1337040000000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Council of University of Tabriz"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    The present study reports a new method for analyzing class 1 residual solvents (\n                    <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>\n                    s), 1,1\u2010dichloroethene (1,1\u2010\n                    <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\n                    ), 1,2\u2010dichloroethane (1,2\u2010\n                    <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\n                    ), 1,1,1\u2010trichloroethane (1,1,1\u2010\n                    <jats:styled-content style=\"fixed-case\">TCE<\/jats:styled-content>\n                    ), carbon tetrachloride (\n                    <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                    ), and benzene (\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    z), in pharmaceutical products using dispersive liquid\u2013liquid microextraction (\n                    <jats:styled-content style=\"fixed-case\">DLLME<\/jats:styled-content>\n                    <jats:bold>)<\/jats:bold>\n                    combined with gas chromatography\u2013flame ionization detection (GC\u2010FID). Unlike common\n                    <jats:styled-content style=\"fixed-case\">DLLME<\/jats:styled-content>\n                    methods, solvents of high boiling point were selected as dispersive and extraction solvents in order to prevent their chromatographic peaks from overlapping with those of analytes that have short retention times. Therefore\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2010dimethyl formamide (\n                    <jats:styled-content style=\"fixed-case\">DMF<\/jats:styled-content>\n                    ) and 1,2\u2010dibromoethane (1,2\u2010\n                    <jats:styled-content style=\"fixed-case\">DBE<\/jats:styled-content>\n                    <jats:bold>)<\/jats:bold>\n                    were chosen as dispersive and extraction solvents, respectively. Analytical parameters of the proposed method were determined and good linearities and broad linear ranges (\n                    <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\n                    s) were obtained. Taking 500 mg samples, limit of detections for the tested pharmaceuticals were obtained as 0.11, 0.03, 0.05, 0.05, and 0.006 \u03bcg g\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                    , 1,1\u2010\n                    <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\n                    , 1,2\u2010\n                    <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\n                    , 1,1,1\u2010\n                    <jats:styled-content style=\"fixed-case\">TCE<\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    z, respectively, which are considerably much lower than their permissible limits in pharmaceuticals.\n                  <\/jats:p>","DOI":"10.1002\/jssc.201100917","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T08:33:58Z","timestamp":1337070838000},"page":"1027-1035","source":"Crossref","is-referenced-by-count":23,"title":["Dispersive liquid\u2013liquid microextraction combined with gas chromatography for extraction and determination of class 1 residual solvents in pharmaceuticals"],"prefix":"10.1002","volume":"35","author":[{"given":"Mir Ali","family":"Farajzadeh","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry University of Tabriz  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Goushjuii","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry University of Tabriz  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djavanshir","family":"Djozan","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry University of Tabriz  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad Kompani","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"21st Street, Kaveh Industrial City Mahban Pharmaceutical Company  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.08.031"},{"key":"e_1_2_7_3_1","first-page":"258","volume":"1","author":"Hermann G. 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