{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:24Z","timestamp":1787314164303,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T00:00:00Z","timestamp":1344297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                    A novel method, dispersive liquid\u2013liquid microextraction combined with liquid chromatography\u2010fluorescence detection is proposed for the determination of three beta\u2010blockers (metoprolol, bisoprolol, and betaxolol) in ground water, river water, and bottled mineral water. Some important parameters, such as the kind and volume of extraction and dispersive solvents, extraction time, pH, and salt effect were investigated and optimized. In the method, a suitable mixture of extraction solvent (60 \u03bcL carbon tetrachloride) and dispersive solvent (1 mL acetonitrile) were injected into the aqueous samples (5.00 mL) and the cloudy solution was observed. After centrifugation, the enriched analytes in the bottom\n                    <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\n                    l\n                    <jats:sub>4<\/jats:sub>\n                    phase were determined by liquid chromatography with fluorescence detection. Under the optimum conditions, the enrichment factors (\n                    <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\n                    s) for metoprolol, bisoprolol, and betaxolol were 180, 190, and 182, and the limits of detection (\n                    <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                    s) were 1.8, 1.4, and 1.0 ng L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. A good linear relationship between the peak area and the concentration of analytes was obtained in the range of 3\u2013150 ng L\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The relative standard deviations (\n                    <jats:styled-content style=\"fixed-case\">RSD<\/jats:styled-content>\n                    s) for the extraction of 10 ng L\n                    <jats:sup>\u22121<\/jats:sup>\n                    of beta\u2010blockers were in the range of 4.6\u20135.7% (\n                    <jats:italic>n<\/jats:italic>\n                    = 5). Compared with other methods, dispersive liquid\u2013liquid microextraction is a very simple, rapid, sensitive (low limit of detection), and economical (only 1.06 mL volume of organic solvent) method, which is in compliance with the requirements of green analytical methodologies.\n                  <\/jats:p>","DOI":"10.1002\/jssc.201200222","type":"journal-article","created":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T04:27:25Z","timestamp":1344313645000},"page":"2184-2192","source":"Crossref","is-referenced-by-count":18,"title":["Simple, rapid, and sensitive determination of beta\u2010blockers in environmental water using dispersive liquid\u2013liquid microextraction followed by liquid chromatography with fluorescence detection"],"prefix":"10.1002","volume":"35","author":[{"given":"Ma del Mar Parrilla","family":"V\u00e1zquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piedad 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