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Spacers of 100\u2010 or 200\u2010\u03bcm high were constructed in a metal substrate with a channel width of 13 mm and the extraction kinetics in these channels was evaluated. The spacers were designed such that at the entrance and exit region a uniform flow distribution could take place and that a uniform flow profile could be guaranteed along the channel, hence allowing a large freedom in sample volume to be processed. The extraction and evaporation kinetic behavior of the device was first evaluated by extraction of a drug candidate (4\u2010(2,5\u2010dimethyl\u2010pyrrol\u20101\u2010y1)\u20102\u2010hydroxybenzoic acid). To evaluate the device under more challenging working conditions, a homogenized mice kidney sample containing the drug candidate that was administered in life condition was cleaned and enriched with the extraction and evaporation modules and characterized by high\u2010performance liquid chromatography, yielding an overall analysis time of 15\u201320 min per sample only. The system has the potential to be operated in a continuous fashion, making it appealing to be implemented in screening or high\u2010throughput applications.<\/jats:p>","DOI":"10.1002\/jssc.201200477","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T08:17:05Z","timestamp":1348042625000},"page":"2407-2413","source":"Crossref","is-referenced-by-count":3,"title":["A membrane microcontactor as a tool for integrated sample preparation"],"prefix":"10.1002","volume":"35","author":[{"given":"Jonas","family":"Hereijgers","sequence":"first","affiliation":[{"name":"\u03bcFlow Department of Chemical Engineering Vrije Universiteit Brussel  Brussels Belgium"},{"name":"Department of Applied Engineering &amp; Technology \u2013 Chemistry Artesis University College  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manly","family":"Callewaert","sequence":"additional","affiliation":[{"name":"\u03bcFlow Department of Chemical Engineering Vrije Universiteit Brussel  Brussels Belgium"},{"name":"B\u2010PHOT Department of Applied Physics Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Breugelmans","sequence":"additional","affiliation":[{"name":"Department of Applied Engineering &amp; Technology \u2013 Chemistry Artesis University College  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Ottevaere","sequence":"additional","affiliation":[{"name":"B\u2010PHOT Department of Applied Physics Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre","family":"Cabooter","sequence":"additional","affiliation":[{"name":"Laboratory for Pharmaceutical Analysis Leuven KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"De Malsche","sequence":"additional","affiliation":[{"name":"\u03bcFlow Department of Chemical Engineering Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573412052953373"},{"key":"e_1_2_7_3_1","first-page":"1120","volume":"19","author":"Leblanc G.","year":"2001","journal-title":"LCGC"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00922-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.08.088"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00934-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00265-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.11.088"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.03.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.11.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00126a030"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20010801)24:7<495::AID-JSSC495>3.0.CO;2-B"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200301455"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac990055n"},{"key":"e_1_2_7_15_1","first-page":"2","volume":"16","author":"J\u00f6nsen J. 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