{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:10:48Z","timestamp":1764936648525,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>The methods for separation of <jats:italic>R,S<\/jats:italic>\u2010tolterodine and <jats:italic>R,S<\/jats:italic>\u2010methoxytolterodine enantiomers using sulfated \u03b1\u2010, \u03b2\u2010CD and phosphated\u2010\u03b3\u2010CD by CE in acidic BGE based on Tris\/phosphate pH 2.5 buffer were developed. Sulfated \u03b1\u2010 and \u03b2\u2010CD allow anodic detection while phosphated\u2010\u03b3\u2010CD allows only cathodic detection of the separated enantiomers. The influence of chiral selector (CS)'s concentration as well as the influence of composition and concentration of BGE on resolutions were studied. Reversal migration order of tolterodine and methoxytolterodine enantiomers was observed, when sulfated\u2010\u03b1\u2010 and sulfated\u2010\u03b2\u2010CD were used. The developed methods with all three studied CSs, were validated and compared. All proposed methods enable determination of 0.2% of <jats:italic>S<\/jats:italic>\u2010tolterodine as an optical impurity in pills, however the method with phosphated\u2010\u03b3\u2010CD provided lower detection limit, better repeatability of peak areas and migration times, and also lower consumption of CS. Developed method employing phosphated\u2010\u03b3\u2010CD that was applied for the determination of optical purity of <jats:italic>R<\/jats:italic>\u2010tolterodine in commercial pills.<\/jats:p>","DOI":"10.1002\/jssc.201200530","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T16:31:20Z","timestamp":1361291480000},"page":"1561-1567","source":"Crossref","is-referenced-by-count":19,"title":["Enantiomeric separation of <i>R,S<\/i>\u2010tolterodine and <i>R,S<\/i>\u2010methoxytolterodine with negatively charged cyclodextrins by capillary electrophoresis"],"prefix":"10.1002","volume":"36","author":[{"given":"Petr","family":"Lehnert","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Science Palack\u00fd University in Olomouc Olomouc Czech Republic"},{"name":"Zentiva, k.s., Prague  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"P\u0159ibylka","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Science Palack\u00fd University in Olomouc Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edt\u011bzslav","family":"Maier","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials Department of Analytical Chemistry Faculty of Science Palack\u00fd University in Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Znaleziona","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials Department of Analytical Chemistry Faculty of Science Palack\u00fd University in Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraj","family":"\u0160ev\u010d\u00edk","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Science Palack\u00fd University in Olomouc Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Dou\u0161a","sequence":"additional","affiliation":[{"name":"Zentiva, k.s., Prague  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003450100224"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855060-00008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.06.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.03.026"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800607"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.071"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac800662y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.02.074"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032711003717448"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201100173"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200290016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.11.094"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900102"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900056"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900173"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.11.018"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac202892w"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305465"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2116\/bunsekikagaku.47.739"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00280-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19991101)20:17<3432::AID-ELPS3432>3.0.CO;2-8"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-667X(1999)11:10<716::AID-MCS4>3.0.CO;2-I"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002160000643"},{"volume-title":"Clarke's Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material,","year":"2004","author":"Moffat A. 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