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Due to the importance in diseases treatment of humans and also of animals, the development of methods for their quantification in commercial formulations is highly desirable. In the present study, a rapid method for simultaneous determination of these compounds using CE with capacitively coupled contactless conductivity detection was developed. A favorable working region for both analytes was from 12.5 to 200 \u03bcmol\/L (linear responses with <jats:italic>R<\/jats:italic> &gt; 0.999 for <jats:italic>N<\/jats:italic> = 5). Other parameters calculated were sensitivity (1.28 \u00b1 0.10\/1.45 \u00b1 0.11) min\/(\u03bcmol L), RSD (4.5%\/2.0%), and <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content> (1.1\/3.3) \u03bcmol\/L for trimethoprim and sulfamethoxazole, respectively. Under this condition, the total run time was only 2.6 min. The proposed method was applied to the determination of trimethoprim and sulfamethoxazole in commercial samples and the results were compared to those obtained by using a <jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content> pharmacopoeia method. This new method is advantageous for quality\u2010control analyses of trimethoprim and sulfamethoxazole in pharmaceuticals samples, because it is rapid and precise. Moreover, it is less laborious and demands minimum amounts of reagents in comparison to the recommended method.<\/jats:p>","DOI":"10.1002\/jssc.201201013","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T08:42:46Z","timestamp":1363768966000},"page":"1405-1409","source":"Crossref","is-referenced-by-count":29,"title":["Fast simultaneous determination of trimethoprim and sulfamethoxazole by capillary zone electrophoresis with capacitively coupled contactless conductivity detection"],"prefix":"10.1002","volume":"36","author":[{"given":"Iranaldo Santos","family":"da Silva","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Companhia de Saneamento Ambiental do Maranh\u00e3o  S\u00e3o Luis MA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis Tadeu Rajh","family":"Vidal","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudimir Lucio","family":"do Lago","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facio","family":"Angnes","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/clinchem\/26.13.1791","volume":"26","author":"Watson I. 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