{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:14:44Z","timestamp":1764432884729,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Two\u2010phase solvent system plays crucial role in successful separation of organic compounds using counter\u2010current chromatography (<jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content>). An interesting two\u2010phase solvent system, composed of chloroform\/ethyl acetate\/methanol\/water, is reported here, in which both phases contain sufficient organic solvents to balance their dissolving capacities. Adjusting the solvent system to get satisfactory partition coefficients (<jats:italic>K<\/jats:italic> values) for target compounds becomes relatively simple. This solvent system succeeded in sample preparation of aconitine (8.07 mg, 93.69%), hypaconitine (7.74 mg, 93.17%), mesaconitine (1.95 mg, 94.52%) from raw aconite roots (102.24 mg, crude extract), benzoylmesaconine (34.79 mg, 98.67%) from processed aconite roots (400.01 mg, crude extract), and yunaconitine (253.59 mg, 98.65%) from a crude extract of <jats:italic>Aconitum forrestii<\/jats:italic> (326.69 mg, crude extract).<\/jats:p>","DOI":"10.1002\/jssc.201201079","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T09:31:56Z","timestamp":1358242316000},"page":"1304-1310","source":"Crossref","is-referenced-by-count":4,"title":["An interesting two\u2010phase solvent system and its use in preparative isolation of aconitines from aconite roots by counter\u2010current chromatography"],"prefix":"10.1002","volume":"36","author":[{"given":"Quan\u2010Bin","family":"Han","sequence":"first","affiliation":[{"name":"School of Chinese Medicine Hong Kong Baptist University Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai\u2010Lun","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine Hong Kong Baptist University Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai\u2010Xia","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine Hong Kong Baptist University Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Xi","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Lab of Quality Research in Chinese Medicine Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Taipa Macau China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1002\/1439-2054(20010301)286:3<161::AID-MAME161>3.0.CO;2-Z"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1016\/j.chroma.2005.10.018"},{"key":"e_1_2_5_4_1","first-page":"390","volume-title":"High\u2010speed Counter\u2010current Chromatography and Its Application","author":"Cao X. 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