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Practical details concerning this technology have rarely been published although it is widely used. This paper now focuses on the practical implementation of precolumn back\u2010flushing for pesticide residue analysis of complex food matrices. Fitting the analytical column into the precolumn was found to be essential for comparable analyte responses with and without back\u2010flushing. The effectiveness of the reverse column flow technique is mainly affected by the transfer time after which back\u2010flushing starts. The transfer time was found to depend on which kind of injected matrix is used and the state of the precolumn. For the regular adaptation of the transfer time in routine analysis, a simple test was introduced in which 13\u2010C\u2010labeled deltamethrin and indeno[1,2,3\u2010c,d]pyrene were added to the prepared extract. Chromatograms, <jats:styled-content style=\"fixed-case\">LOQ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RSD<\/jats:styled-content> of up to 99 pesticides in citrus oil and liver extracts proved a clearer identification and enhanced quantification using precolumn back\u2010flushing compared to measurements without this technology. Furthermore, reduced system maintenance could be achieved through back\u2010flushing.<\/jats:p>","DOI":"10.1002\/jssc.201300007","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T12:53:07Z","timestamp":1366289587000},"page":"2128-2135","source":"Crossref","is-referenced-by-count":8,"title":["Application of the precolumn back\u2010flush technology in pesticide residue analysis: A practical view"],"prefix":"10.1002","volume":"36","author":[{"given":"Fanny","family":"Hildmann","sequence":"first","affiliation":[{"name":"Department of Pesticides, Saxon State Laboratory of Health and Veterinary Affairs Dresden Germany"},{"name":"Institute of Food Chemistry Technical University Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Kempe","sequence":"additional","affiliation":[{"name":"Department of Pharmacologically Active Substances, Saxon State Laboratory of Health and Veterinary Affairs Chemnitz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Speer","sequence":"additional","affiliation":[{"name":"Institute of Food Chemistry Technical University Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240160812"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.01.018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240200706"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200900358"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)01145-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00539-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.04.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00066a020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/an9911601313"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240131004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(93)83372-Y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240160714"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.01.027"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2011.12.015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200600064"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1132"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)01253-X"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.05.004"},{"key":"e_1_2_7_20_1","first-page":"32","author":"Prest H.","year":"2008","journal-title":"LC GC Eur."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.09.094"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.04.005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuproc.2011.07.011"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200169"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/jaoac\/92.6.1790","volume":"92","author":"Mezuca M.","year":"2009","journal-title":"J. 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