{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:36:15Z","timestamp":1761510975018,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21175153","21275133"],"award-info":[{"award-number":["21175153","21275133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Tobacco\u2010specific <jats:italic>N<\/jats:italic>\u2010nitrosamines (TSNAs), including <jats:italic>N<\/jats:italic>\u2032\u2010nitrosonornicotine, 4\u2010(methylnitrosamino)\u20101\u2010(3\u2010pyridyl)\u20101\u2010butanone, <jats:italic>N<\/jats:italic>\u2032\u2010nitrosoanatabine, and <jats:italic>N<\/jats:italic>\u2032\u2010nitrosoanabasine, have been implicated as a source of carcinogenicity in tobacco and cigarette smoke. We present a rapid and effective method comprising SPE based on tetraazacalix[2]arene[2]triazine\u2010modified silica as sorbent and analysis with HPLC\u2013MS\/MS for the determination of TSNAs and 4\u2010(methylnitrosamino)\u20101\u2010(3\u2010pyridyl)\u20101\u2010butanol (NNAL), a metabolite of 4\u2010(methylnitrosamino)\u20101\u2010(3\u2010pyridyl)\u20101\u2010butanone, in rabbit plasma. The linear dynamic ranges were 10\u20132000 pg\/mL for NNAL and 4\u20132000 pg\/mL for the four TSNAs with good correlation coefficients (&gt;0.9965). The LODs were in the range of 0.9\u20133.7 pg\/mL, and the LOQs were between 2.9 and 12.3 pg\/mL. The accuracies of the method were also evaluated and found to be in the range of 90.1\u2013113.3%. This method is promising to be applied to the preconcentration and determination of TSNAs and NNAL in smoke and human body fluids.<\/jats:p>","DOI":"10.1002\/jssc.201300219","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T03:59:35Z","timestamp":1371009575000},"page":"2664-2671","source":"Crossref","is-referenced-by-count":21,"title":["SPE\u2013HPLC\u2013MS\/MS method for the trace analysis of tobacco\u2010specific <i>N<\/i>\u2010nitrosamines and 4\u2010(methylnitrosamino)\u20101\u2010(3\u2010pyridyl)\u20101\u2010butanol in rabbit plasma using tetraazacalix[2]arene[2]triazine\u2010modified silica as a sorbent"],"prefix":"10.1002","volume":"36","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Zhengzhou Tobacco Research Institute of CNTC  Zhengzhou P.R. China"},{"name":"Chemistry Department, Key Laboratory of Chemical Biology and Organic Chemistry of Henan Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhengzhou Tobacco Research Institute of CNTC  Zhengzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhengzhou Tobacco Research Institute of CNTC  Zhengzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhengzhou Tobacco Research Institute of CNTC  Zhengzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailei","family":"Lang","sequence":"additional","affiliation":[{"name":"Zhengzhou Tobacco Research Institute of CNTC  Zhengzhou P.R. 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