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Two versatile techniques, HPLC<\/jats:styled-content> and supercritical fluid chromatography (SFC<\/jats:styled-content>) were used in this study. CHIRALPAK IC<\/jats:styled-content> has shown superior selectivity under both LC<\/jats:styled-content> and SFC<\/jats:styled-content> conditions, whereas CHIRALPAK IA<\/jats:styled-content> has shown good selectivity in SFC<\/jats:styled-content> when compared to LC<\/jats:styled-content> under primary screening conditions. The chiral recognition ability in LC<\/jats:styled-content> and SFC<\/jats:styled-content> modes were found to be in the order CHIRALPAK IC<\/jats:styled-content> > CHIRALPAK IA<\/jats:styled-content> > CHIRALPAK IB<\/jats:styled-content>. In addition to diode array detection, chiral detection was carried out using a laser polarimeter and the elution orders were found to be the same in both LC<\/jats:styled-content> and SFC<\/jats:styled-content> elution modes. Mobile phase modifiers and column temperature effects were also studied. In SFC<\/jats:styled-content>, modifiers (cosolvent) elution strength was found to be in the order ethanol > methanol > 2\u2010propanol > acetonitrile. In both LC<\/jats:styled-content> and SFC<\/jats:styled-content>, a decrease in retention and increase in resolution with an increase in temperature was noticed for all the proton pump inhibitors.<\/jats:p>","DOI":"10.1002\/jssc.201300419","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T05:10:51Z","timestamp":1373951451000},"page":"3004-3010","source":"Crossref","is-referenced-by-count":23,"title":["Enantiomeric separation of proton pump inhibitors on new generation chiral columns using LC<\/scp> and supercritical fluid chromatography"],"prefix":"10.1002","volume":"36","author":[{"given":"Lakshmi Narayana","family":"Chennuru","sequence":"first","affiliation":[{"name":"Daicel Chiral Technologies (India) Pvt. 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