{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:36:55Z","timestamp":1787791015709,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Basic Research Program of China","award":["2012CB524900"],"award-info":[{"award-number":["2012CB524900"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The development of an <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content> method for the separation of aripiprazole and its nine impurities was performed with the use of partial least squares regression, response surface plot methodology, and chromatographic response function. The <jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content> retention times and computed molecular parameters of the aripiprazole and its nine impurities were further used for the quantitative structure\u2013retention relationship (<jats:styled-content style=\"fixed-case\">QSRR<\/jats:styled-content>) study. The <jats:styled-content style=\"fixed-case\">QSRR<\/jats:styled-content> model, <jats:italic><jats:styled-content style=\"fixed-case\">R<\/jats:styled-content><\/jats:italic><jats:sup>2<\/jats:sup>: 0.899, <jats:italic><jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content><\/jats:italic><jats:sup>2<\/jats:sup>: 0.832, root mean square error of estimation: 4.761, root mean square error of prediction: 6.614, was developed. Very good agreement between the predicted and observed retention times (<jats:italic>t<\/jats:italic><jats:sub>R<\/jats:sub>) for three additional aripiprazole impurities (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>1\u2013<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>3) indicated the high prediction potential of the <jats:styled-content style=\"fixed-case\">QSRR<\/jats:styled-content> model for <jats:italic>t<\/jats:italic><jats:sub>R<\/jats:sub> evaluation of other aripiprazole impurities and metabolites. The developed <jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content> method is the first reported method for the efficient separation of aripiprazole and its nine impurities, which could be used for the analysis of an additional three aripiprazole impurities (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>1\u2013<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>3).<\/jats:p>","DOI":"10.1002\/jssc.201300477","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T04:29:08Z","timestamp":1375244948000},"page":"3165-3175","source":"Crossref","is-referenced-by-count":16,"title":["Development of a novel <scp>RP<\/scp>\u2010<scp>HPLC<\/scp> method for the efficient separation of aripiprazole and its nine impurities"],"prefix":"10.1002","volume":"36","author":[{"given":"Katarina","family":"Nikolic","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Chemistry Faculty of Pharmacy University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nata\u0161a Djordjevi\u0107","family":"Filijovi\u0107","sequence":"additional","affiliation":[{"name":"Hemofarm AD  Vr\u0161ac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borislava","family":"Mari\u010di\u0107","sequence":"additional","affiliation":[{"name":"Hemofarm AD  Vr\u0161ac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Agbaba","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Chemistry Faculty of Pharmacy University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"AHFS Drug Information American Society of Health\u2010System Pharmacists Bethesda 2008 2446\u20132448."},{"key":"e_1_2_7_3_1","volume-title":"Basic and Clinical Pharmacology, Antipsychotic Agents and Lithium","author":"Katzung BG.","year":"2004"},{"key":"e_1_2_7_4_1","unstructured":"ICH Q3A (R2) CPMP\/ICH\/2737\/99\u2010ICH Q3A (R2) Impurities Testing Guideline: Impurities in New Drug Substances EMEA 2006."},{"key":"e_1_2_7_5_1","unstructured":"ICH Q3B (R2) CPMP\/ICH\/2738\/99\u2010ICH Q3B (R2) Impurities in new drug products EMEA2006."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2011.04.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.01.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.05.026"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.06.023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2008.11.027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201000457"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.02.026"},{"key":"e_1_2_7_13_1","first-page":"81","volume":"24","author":"Ding H.","year":"2005","journal-title":"Dongnan Daxue Xuebao Yixueban"},{"key":"e_1_2_7_14_1","first-page":"137","volume":"39","author":"Jianpeng Z.","year":"2005","journal-title":"Chinese Pharm. 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