{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:35:02Z","timestamp":1788870902810,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21105090"],"award-info":[{"award-number":["21105090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"crossref","award":["Y4100472"],"award-info":[{"award-number":["Y4100472"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    This paper extends the research of the utilization of borate coordination complexes in chiral separation by counter\u2010current chromatography (\n                    <jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content>\n                    ). Racemic propafenone was successfully enantioseparated by\n                    <jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content>\n                    with di\u2010\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butyl\n                    <jats:sc>l<\/jats:sc>\n                    \u2010tartrate combined with boric acid as the chiral selector. The two\u2010phase solvent system was composed of chloroform\/ 0.05 mol\/L acetate buffer pH 3.4 containing 0.10 mol\/L boric acid (1:1, v\/v), in which 0.10 mol\/L di\u2010\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butyl\n                    <jats:sc>l<\/jats:sc>\n                    \u2010tartrate was added in the organic phase. The influence of factors in the enantioseparation of propafenone were investigated and optimized. A total of 92 mg of racemic propafenone was completely enantioseparated using high\u2010speed\n                    <jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content>\n                    in a single run, yielding 40\u201342 mg of (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\n                    <\/jats:italic>\n                    )\u2010 and (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                    <\/jats:italic>\n                    )\u2010propafenone enantiomers with an\n                    <jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>\n                    purity over 90\u201395%. The recovery for propafenone enantiomers from fractions of\n                    <jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content>\n                    was in the range of 85\u201390%.\n                  <\/jats:p>","DOI":"10.1002\/jssc.201300614","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T05:12:42Z","timestamp":1373951562000},"page":"3101-3106","source":"Crossref","is-referenced-by-count":9,"title":["Preparative enantioseparation of propafenone by counter\u2010current chromatography using di\u2010\n                    <i>n<\/i>\n                    \u2010butyl\n                    <scp>l<\/scp>\n                    \u2010tartrate combined with boric acid as the chiral selector"],"prefix":"10.1002","volume":"36","author":[{"given":"Shengqiang","family":"Tong","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangmang","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Chu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Nuo","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhong","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.102"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(99)00083-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00652-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(98)00444-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.08.024"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20010901)24:9<795::AID-JSSC795>3.0.CO;2-V"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20021101)25:15\/17<1269::AID-JSSC1269>3.0.CO;2-R"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1439-2054(20010301)286:3<161::AID-MAME161>3.0.CO;2-Z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00499-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201300193"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200600058"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198911473"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.43.262"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.44.1521"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.44.1250"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2006.07.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.09.023"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.06.023"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.06.015"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02327970"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201300614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201300614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.201300614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:09:20Z","timestamp":1760864960000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.201300614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,6]]},"references-count":20,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/jssc.201300614"],"URL":"https:\/\/doi.org\/10.1002\/jssc.201300614","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,6]]}}}