{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:43:55Z","timestamp":1760921035646,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Communitys social foundation","award":["VP1- 3.1-SMM-08-K-01-004\/KS-120000-1756"],"award-info":[{"award-number":["VP1- 3.1-SMM-08-K-01-004\/KS-120000-1756"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2014,3]]},"abstract":"An SPE<\/jats:styled-content> procedure for the determination of zaleplon and zopiclone in low\u2010volume human hemolyzed blood using fast GC<\/jats:styled-content> with negative\u2010ion chemical ionization MS<\/jats:styled-content> has been developed and validated. Both analytes were well retained on O<\/jats:styled-content>asis MCX<\/jats:styled-content> and HLB<\/jats:styled-content> columns, and sufficient extraction efficiency was achieved at pH 9.0. For further study a hydrophilic\u2010lipophilic sorbent O<\/jats:styled-content>asis HLB<\/jats:styled-content> was selected due to the polarity of sorbent surface and its large surface area in order to achieve efficient extraction of both analytes in a single step. Special attention has been paid to choosing washing and eluting solvents, resulting in a particularly\/extremely clean and moisture\u2010free extract. The mean extraction efficiency was higher than 90.1% for zaleplon and 82.9% for zopiclone. The precision for zaleplon and zopiclone was between 3.04\u201310.58% and 4.08\u20139.52%, respectively. Whereas the accuracy was in the range from \u20135.73 to 6.00%, and from \u20137.00 to 6.32% for zaleplon and zopiclone, respectively. The results show that the developed method is accurate, selective, precise, and very fast with excellent recovery and low LOD<\/jats:styled-content> and LOQ<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/jssc.201300784","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T08:58:48Z","timestamp":1388048328000},"page":"551-557","source":"Crossref","is-referenced-by-count":5,"title":["Development of an SPE<\/scp> method for the determination of zaleplon and zopiclone in hemolyzed blood using fast GC<\/scp> with negative\u2010ion chemical ionization MS<\/scp>"],"prefix":"10.1002","volume":"37","author":[{"given":"Nerijus","family":"Karlonas","sequence":"first","affiliation":[{"name":"Center of Nanotechnology and Material Science Department of Analytical and Environmental Chemistry Faculty of Chemistry Vilnius University Vilnius Lithuania"},{"name":"State Forensic Medicine Service Under the Ministry of Justice of the Republic of Lithuania Vilnius 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